Gender differences in the prevalence and clinical correlates of suicide attempts in young first-episode drug-naïve major depressive disorder patients with thyroid dysfunction.

Autor: Liu L; Department of Psychiatry, Shenzhen Nanshan People's Hospital, No 89, Taoyuan Road, Nanshan District, Shenzhen, 518052, PR China., Zhou J; Department of Psychiatry, Shenzhen Nanshan People's Hospital, No 89, Taoyuan Road, Nanshan District, Shenzhen, 518052, PR China., Song X; Department of Psychiatry, Shenzhen Nanshan People's Hospital, No 89, Taoyuan Road, Nanshan District, Shenzhen, 518052, PR China., Luo G; Department of Psychiatry, Shenzhen Nanshan People's Hospital, No 89, Taoyuan Road, Nanshan District, Shenzhen, 518052, PR China., Peng M; Department of Psychiatry, Shenzhen Nanshan People's Hospital, No 89, Taoyuan Road, Nanshan District, Shenzhen, 518052, PR China. mindy_peng@163.com., Zhang X; CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, 16 Lincui Road, Chaoyang District, Beijing, 100101, PR China. zhangxy@psych.ac.cn.; Department of Psychology, University of Chinese Academy of Sciences, Beijing, China. zhangxy@psych.ac.cn.
Jazyk: angličtina
Zdroj: BMC psychiatry [BMC Psychiatry] 2024 Dec 04; Vol. 24 (1), pp. 880. Date of Electronic Publication: 2024 Dec 04.
DOI: 10.1186/s12888-024-06332-8
Abstrakt: Thyroid dysfunction is commonly seen in major depressive disorder (MDD), and is particularly prevalent in female patients. Moreover, gender differences occur in many aspects of MDD, including suicide attempts (SAs). We aimed to explore gender differences in the prevalence and clinical correlates of SAs in young first-episode drug-naïve MDD patients with thyroid dysfunction, which have not yet been reported. We recruited 509 patients in this study. Demographic and clinical characteristics were collected. We used HAMD-17, HAMA-14, the positive subscale of PANSS, and CGI-S to assess every participant. We found no significant difference in the prevalence of SAs between male and female subgroup. Gender differences in factors associated with SAs were found with anxiety, body mass index, serum anti-thyroid antibodies (A-TPO), and free triiodothyronine levels in male patients and anxiety, CGI-S score, and A-TPO in female patients. We found no gender differences in the prevalence of SAs; however, there were gender differences in several clinical correlates of SAs, highlighting specific strategies to avoid SAs in male and female MDD patients.
Competing Interests: Declarations. Ethics approval and consent to participate: The study was approved by the medical ethics committee at the First Hospital of Shanxi Medical University. Informed consent was obtained from all subjects and/or their legal guardian(s). Consent for publication: Not applicable. Competing interests: The authors declare no competing interests.
(© 2024. The Author(s).)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje