Association between gastroesophageal reflux disease and tinnitus in a nationwide population-based cohort study.

Autor: Kang SW; Department of Internal Medicine, Kyung Hee University College of Korean Medicine, Seoul, 02447, Korea., An MH; Department of Biomedical Informatics, Ajou University School of Medicine, Suwon, 16499, Korea.; Department of Medical Sciences, Ajou University Graduate School of Medicine, Suwon, 16499, Korea., Ha S; Department of Acupuncture and Moxibustion Medicine, Sangji University College of Korean Medicine, Wonju, 26339, Korea., Kim MG; Department of Biomedical Informatics, Ajou University School of Medicine, Suwon, 16499, Korea.; Department of Medical Sciences, Ajou University Graduate School of Medicine, Suwon, 16499, Korea., Park TJ; Department of Medical Sciences, Ajou University Graduate School of Medicine, Suwon, 16499, Korea.; Department of Biochemistry and Molecular Biology, Ajou University School of Medicine, Suwon, 16499, Korea.; Inflamm-Aging Translational Research Center, Ajou University Medical Center, Suwon, 16499, Korea., Kim HK; Department of Brain Science and Neurology, Ajou University School of Medicine, Suwon, 16499, Korea., Sheen K; Department of Biomedical Science and Technology, Kyung Hee University, Seoul, 02447, Korea., Park RW; Department of Biomedical Informatics, Ajou University School of Medicine, Suwon, 16499, Korea.; Department of Medical Sciences, Ajou University Graduate School of Medicine, Suwon, 16499, Korea., Park SS; Department of Medical Sciences, Ajou University Graduate School of Medicine, Suwon, 16499, Korea. sspark9395@ajou.ac.kr.; Department of Biochemistry and Molecular Biology, Ajou University School of Medicine, Suwon, 16499, Korea. sspark9395@ajou.ac.kr.; Inflamm-Aging Translational Research Center, Ajou University Medical Center, Suwon, 16499, Korea. sspark9395@ajou.ac.kr.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Dec 03; Vol. 14 (1), pp. 30106. Date of Electronic Publication: 2024 Dec 03.
DOI: 10.1038/s41598-024-81658-7
Abstrakt: Gastroesophageal Reflux Disease (GERD) is characterized by the regurgitation of stomach contents. Recent research indicates that acid reflux may disrupt the homeostasis of the middle and inner ear through the Eustachian tube. Given this context, we hypothesized that an association between GERD and tinnitus may exist due to the imbalance of the middle and inner ear caused by acid reflux. To explore this connection, we conducted a retrospective cohort study involving 669,159 patients registered in the National Health Insurance Service-National Sample Cohort (2012-2019) in South Korea. Our data showed that GERD and tinnitus are highly associated. Nevertheless, the use of proton pump inhibitor medication in GERD patients did not show a significant decrease in the onset of tinnitus.
Competing Interests: Declarations. Competing interests: The authors declare no competing interests. Ethics approval: The retrospective cohort study was conducted under an informed consent waiver approved by the Institutional Review Board (IRB) at Ajou University Hospital (AJOUIRB-EX-2023–146).
(© 2024. The Author(s).)
Databáze: MEDLINE
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