Long non-coding RNAs and their role in breast cancer pathogenesis and drug resistance: Navigating the non-coding landscape review.

Autor: Al-Noshokaty TM; Department of Biochemistry, Faculty of Pharmacy, Heliopolis University, Cairo, 11785, Egypt., El-Sayyad GS; Department of Medical Laboratory Technology, Faculty of Applied Health Sciences Technology, Badr University in Cairo (BUC), Badr, Cairo, 11829, Egypt; Microbiology and Immunology Department, Faculty of Pharmacy, Galala University, New Galala City, Suez, Egypt; Microbiology and Immunology Department, Faculty of Pharmacy, Ahram Canadian University (ACU), 6th October City, Giza, Egypt. Electronic address: Gharieb.Elsayyad@acu.edu.eg., Abdelhamid R; Department of Biochemistry, Faculty of Pharmacy, Heliopolis University, Cairo, 11785, Egypt., Mansour A; Department of Biochemistry, Faculty of Pharmacy, Heliopolis University, Cairo, 11785, Egypt., Abdellatif N; Department of Biochemistry, Faculty of Pharmacy, Heliopolis University, Cairo, 11785, Egypt., Alaaeldien A; Department of Biochemistry, Faculty of Pharmacy, Heliopolis University, Cairo, 11785, Egypt., Reda T; Department of Biochemistry, Faculty of Pharmacy, Heliopolis University, Cairo, 11785, Egypt., Gendi D; Department of Biochemistry, Faculty of Pharmacy, Heliopolis University, Cairo, 11785, Egypt., Abdelmaksoud NM; Department of Biochemistry, Faculty of Pharmacy, Heliopolis University, Cairo, 11785, Egypt., Elshaer SS; Department of Biochemistry, Faculty of Pharmacy, Heliopolis University, Cairo, 11785, Egypt; Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Girls), Al-Azhar University, Nasr City, Cairo, 11823, Egypt., Doghish AS; Department of Biochemistry, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr, Cairo, 11829, Egypt; Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, Cairo, 11231, Egypt. Electronic address: ahmed_doghish@azhar.edu.eg., Mohammed OA; Department of Pharmacology, College of Medicine, University of Bisha, Bisha, 61922, Saudi Arabia., Abulsoud AI; Department of Biochemistry, Faculty of Pharmacy, Heliopolis University, Cairo, 11785, Egypt; Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, Cairo, 11231, Egypt.
Jazyk: angličtina
Zdroj: Experimental cell research [Exp Cell Res] 2024 Dec 01; Vol. 444 (2), pp. 114365. Date of Electronic Publication: 2024 Dec 01.
DOI: 10.1016/j.yexcr.2024.114365
Abstrakt: Despite the progress made in the development of targeted therapies, breast cancer (BC) continues to pose a significant threat to the health of women. Transcriptomics has emerged due to the advancements in high-throughput sequencing technology. This provides crucial information about the role of non-coding RNAs (ncRNAs) in human cells, particularly long ncRNAs (lncRNAs), in disease development and function. When the control of these ncRNAs is disrupted, various illnesses emerge, including cancer. Numerous studies have produced empirical data on the function of lncRNAs in tumorigenesis and disease development. However, the roles and mechanisms of numerous lncRNAs remain unidentified at the molecular level because their regulatory role and the functional implications of abnormalities in cancer biology have yet to be thoroughly defined. The review gives an itemized summary of the most current developments in the role of lncRNA in BC, focusing on three main pathways, PI3K, MAPK, NF-kB, and hypoxia, and their resistance mechanisms.
Competing Interests: Declaration of competing interest There is no competing interest.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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