Diagnostic and Prognostic Value of SCUBE-1 in COVID-19 Patients.

Autor: Ozer V; Karadeniz Technical University, School of Medicine, Department of Emergency Medicine, Trabzon, Türkiye., Gonenc Cekic O; SBU Kanuni Training and Research Hospital, Department of Emergency Medicine, Trabzon, Türkiye., Bulbul O; Karadeniz Technical University, School of Medicine, Department of Emergency Medicine, Trabzon, Türkiye., Aydın D; SBU Kanuni Training and Research Hospital, Department of Chest Diseases, Division of Intensive Care Medicine, Trabzon, Türkiye., Bulut E; SBU Kanuni Training and Research Hospital, Department of Radiology, Trabzon, Türkiye., Aksoy F; Karadeniz Technical University, School of Medicine, Department of Infectious Diseases and Clinical Microbiology, Trabzon, Türkiye., Pehlivanlar Kucuk M; Karadeniz Technical University, School of Medicine, Department of Chest Diseases, Division of Intensive Care Medicine, Trabzon, Türkiye., Caner Karahan S; Karadeniz Technical University, School of Medicine, Department of Biochemistry, Trabzon, Türkiye., Emel Sozen E; SBU Kanuni Training and Research Hospital, Department of Infectious Diseases and Clinical Microbiology, Trabzon, Türkiye., Ozkaya E; Karadeniz Technical University, School of Medicine, Department of Medical Microbiology, Trabzon, Türkiye., Kosucu P; Karadeniz Technical University, School of Medicine, Department of Radiology, Trabzon, Türkiye., Karaca Y; Karadeniz Technical University, School of Medicine, Department of Emergency Medicine, Trabzon, Türkiye., Turedi S; SBU Kanuni Training and Research Hospital, Department of Emergency Medicine, Trabzon, Türkiye.
Jazyk: angličtina
Zdroj: The western journal of emergency medicine [West J Emerg Med] 2024 Nov; Vol. 25 (6), pp. 975-984.
DOI: 10.5811/westjem.18586
Abstrakt: Introduction: The workload of physicians increased due to the number of patients presenting with suspicion of coronavirus 2019 (COVID-19) and the prolonged wait times in the emergency department during the COVID-19 pandemic. Signal peptide-CUB-EGF domain-containing protein 1 (SCUBE-1) is a protein present in platelets and endothelial cells; it is activated by inflammation from COVID-19 and may be associated with COVID-19's known thrombotic risk. We aimed to determine whether SCUBE-1 levels are diagnostically correlated in suspected COVID-19 patients, and whether SCUBE-1 correlated with severity of disease and, therefore, might be useful to guide hospitalization/discharge decisions.
Methods: The suspected COVID-19 patients cared for at tertiary healthcare institutions for one year between May 2021-May 2022 were examined in this study. The subjects were both suspected COVID-19 patients not ultimately found to have COVID-19 and those who were diagnosed with COVID-19. By modifying the disease severity scoring systems present in COVID-19 guidelines in 2021, the COVID-19-positive patient group was classified as mild, moderate, severe, and critical, and compared using the SCUBE-1 levels. Moreover, SCUBE-1 levels were compared between the COVID-19 positive group and the COVID-19 negative group.
Results: A total of 507 patients were considered for the present study. After excluding 175 patients for incomplete data and alternate comorbid organ failure. we report on 332 patients (65.5%). Of these 332 patients, 80 (24.0%) were COVID-19 negative, and 252 (76.0%) were COVID-19 positive. Of 252 (100%) patients diagnosed with COVID-19, 74 (29.4%) were classified as mild, 95 (37.7%) moderate, 45 (17.8%) severe, and 38 (15.1%) critical. The SCUBE-1 levels were statistically different between COVID-19 positive (8.48 ± 7.42 nanograms per milliliter [ng/mL]) and COVID-19 negative (1.86 ± 0.92 ng/mL) patients ( P  < 0.001). In the COVID-19 positive group, SCUBE-1 levels increased with disease severity (mild = 3.20 ± 1.65 ng/mL, moderate = 4.78 ± 2.26 ng/mL, severe = 13.68 ± 3.95 ng/mL, and critical = 21.87 ± 5.39 ng/mL) ( P  < 0.001). The initial SCUBE-1 levels of discharged patients were significantly lower than those requiring hospitalization (discharged = 2.89 ng/mL [0.55-8.60 ng/mL]; ward admitted = 7.13 ng/mL [1.38-21.29 ng/mL], and ICU admitted = 21.19 ng/mL [10.58-37.86 ng/mL]) ( P  < 0.001).
Conclusion: The SCUBE-1 levels were found to be differentiated between patients with and without COVID-19 and to be correlated with the severity of illness.
Competing Interests: Conflicts of Interest: By the WestJEM article submission agreement, all authors are required to disclose all affiliations, funding sources and financial or management relationships that could be perceived as potential sources of bias. This project was supported by Karadeniz Technical University Scientific Research Projects Coordination Unit. Project Number THD-2021-9753. There are no other conflicts of interest or sources of funding to declare.
Databáze: MEDLINE
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