Edaravone's reno-protective effects against chronic heat-stress exposure.

Autor: Alquraan LT; Department of Biological Sciences, The Faculty of Science, Yarmouk University, Irbid, Jordan., Alzoubi KH; Department of Pharmacy Practice and Pharmacotherapeutics, College of Pharmacy, University of Sharjah, Sharjah, UAE. khalzoubi@just.edu.jo.; Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan. khalzoubi@just.edu.jo., Jaber S; Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan., Khabour OF; Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, Jordan University of Science and Technology, Irbid, Jordan., Al-Trad B; Department of Biological Sciences, The Faculty of Science, Yarmouk University, Irbid, Jordan., Al-Shwaheen A; Department of Biological Sciences, The Faculty of Science, Yarmouk University, Irbid, Jordan., Alomari G; Department of Biological Sciences, The Faculty of Science, Yarmouk University, Irbid, Jordan., Rababa'h SY; Department of Pharmacy, Faculty of Pharmacy, Jadara University, Irbid, Jordan., Masadeh MM; Department of Pharmaceutical Technology, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan.
Jazyk: angličtina
Zdroj: Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2024 Dec 03. Date of Electronic Publication: 2024 Dec 03.
DOI: 10.1007/s00210-024-03685-5
Abstrakt: Edaravone (EDV) is a potent antioxidant with anti-inflammatory properties. It is used to treat various diseases, especially neurodegenerative diseases. This study aims to examine EDV's potential renal protective effects on kidney injury induced by heat stress in rats. Male Wistar rats were segregated into four distinct groups (n = 16/group): control (Ctr), heat stress (HS), edaravone (EDV), and HS+EDV groups. Heat stress was applied 6 days a week for 30 min for 8 weeks, and EDV treatment (6 mg/kg. IP) was administered simultaneously in the HS+EDV group. After the experiment, blood and kidney tissue samples were gathered for subsequent analysis. Compared to the control group, the HS group exhibited a significant increase in serum creatinine and urea levels (P < 0.05). Additionally, malondialdehyde level and catalase activity, tumor necrosis factor-α (TNF-α), and interleukin-1 beta (IL-1β) mRNA expression were increased in the kidney tissue during HS. The renal tissues of the heat-stressed animal showed noticeable histological alterations compared to the control group. However, in the HS+EDV and EDV groups, the creatinine and urea concentrations in the blood were markedly reduced compared to the HS group (P < 0.05). In addition, renal oxidative stress biomarkers were normalized (malondialdehyde levels and catalase activity; P < 0.05). The histopathological alterations in the renal tissues of the groups treated with EDV were markedly diminished. In addition, the renal mRNA expression levels of IL-1β and TNF-α were markedly reduced in the HS+EDV group compared to the HS group (P < 0.05). EDV treatment in a heat-stress rat model demonstrated a protective effect on renal tissue, most likely due to its antioxidant and anti-inflammatory properties.
Competing Interests: Declarations. Ethics approval and consent to participate: The experimental protocol for this study was approved by the Institutional Animal Care and Use Committee of Jordan University of Science and Technology, IACUC-JUST, approval number IACUC/443/2022. Competing interests: The authors declare no competing interests.
(© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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