Malignant transformation of post-radiation induced erosive lichen planus to squamous cell carcinoma.

Autor: Regester RM; Department of Dermatology University of Nebraska Medical Center Omaha Nebraska USA., Kwan KR; Department of Dermatology University of Nebraska Medical Center Omaha Nebraska USA., Fernandez JM; Department of Dermatology University of Nebraska Medical Center Omaha Nebraska USA., Sutton A; Department of Dermatology University of Nebraska Medical Center Omaha Nebraska USA., Arthur M; Department of Dermatology University of Nebraska Medical Center Omaha Nebraska USA.
Jazyk: angličtina
Zdroj: Skin health and disease [Skin Health Dis] 2024 Aug 24; Vol. 4 (6), pp. e443. Date of Electronic Publication: 2024 Aug 24 (Print Publication: 2024).
DOI: 10.1002/ski2.443
Abstrakt: Radiation therapy is commonly used to treat various types of malignancies during or after radiation. Approximately 95% percent of patients develop common skin manifestations including dermatitis, atrophy and fibrosis. Rare manifestations, including non-melanoma skin cancers, morphea, cutaneous angiosarcoma and bullous pemphigoid, have been reported post-treatment. The development of lichen planus (LP) from radiation therapy is exceedingly rare, with only 14 previous cases reported. Of these, none were associated with malignant transformation. Malignant transformation from LP is uncommon, with reported cases mainly in oral manifestations of LP at rates of ∼1%-2%. Classic cutaneous manifestations of LP have not been associated with an increased risk of malignancy. We report a unique case of erosive cutaneous LP with malignant transformation in a previously radiated site. Our case highlights a novel cutaneous adverse event to radiation treatment and emphasises the importance of considering erosive LP on the differential when evaluating recalcitrant erosions in a previously radiated area and to monitor closely for transformation to squamous cell carcinoma.
Competing Interests: The authors declare that they have no conflicts of interest.
(© 2024 The Author(s). Skin Health and Disease published by John Wiley & Sons Ltd on behalf of British Association of Dermatologists.)
Databáze: MEDLINE
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