Neddylation steers the fate of cellular receptors.

Autor: Park JB; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea.; Ischemic/Hypoxic Disease Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.; Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Lee MY; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea.; Ischemic/Hypoxic Disease Institute, Seoul National University College of Medicine, Seoul, Republic of Korea., Lee J; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea.; Ischemic/Hypoxic Disease Institute, Seoul National University College of Medicine, Seoul, Republic of Korea., Moon GH; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea.; Ischemic/Hypoxic Disease Institute, Seoul National University College of Medicine, Seoul, Republic of Korea., Kim SJ; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea.; Ischemic/Hypoxic Disease Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.; Department of Physiology, Seoul National University College of Medicine, Seoul, Republic of Korea., Chun YS; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea. chunys@snu.ac.kr.; Ischemic/Hypoxic Disease Institute, Seoul National University College of Medicine, Seoul, Republic of Korea. chunys@snu.ac.kr.; Department of Physiology, Seoul National University College of Medicine, Seoul, Republic of Korea. chunys@snu.ac.kr.
Jazyk: angličtina
Zdroj: Experimental & molecular medicine [Exp Mol Med] 2024 Dec; Vol. 56 (12), pp. 2569-2577. Date of Electronic Publication: 2024 Dec 02.
DOI: 10.1038/s12276-024-01358-0
Abstrakt: Cellular receptors regulate physiological responses by interacting with ligands, thus playing a crucial role in intercellular communication. Receptors are categorized on the basis of their location and engage in diverse biochemical mechanisms, which include posttranslational modifications (PTMs). Considering the broad impact and diversity of PTMs on cellular functions, we focus narrowly on neddylation, a modification closely resembling ubiquitination. We systematically organize its canonical and noncanonical roles in modulating proteins associated with cellular receptors with the goal of providing a more detailed perspective on the intricacies of both intracellular and cell-surface receptors.
Competing Interests: Competing interests: The authors declare no competing interests.
(© 2024. The Author(s).)
Databáze: MEDLINE
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