Enhancing fMRI quality control.

Autor: van den Berg L; Department of Neurology & Neurosurgery, UMC Utrecht Brain Center, Heidelberglaan 100, Utrecht 3582 CX, the Netherlands., Ramsey N; Department of Neurology & Neurosurgery, UMC Utrecht Brain Center, Heidelberglaan 100, Utrecht 3582 CX, the Netherlands., Raemaekers M; Department of Neurology & Neurosurgery, UMC Utrecht Brain Center, Heidelberglaan 100, Utrecht 3582 CX, the Netherlands. Electronic address: m.raemaekers-2@umcutrecht.nl.
Jazyk: angličtina
Zdroj: Journal of neuroscience methods [J Neurosci Methods] 2024 Nov 30; Vol. 415, pp. 110337. Date of Electronic Publication: 2024 Nov 30.
DOI: 10.1016/j.jneumeth.2024.110337
Abstrakt: Background: fMRI in clinical settings faces challenges affecting activity maps. Template matching can screen for abnormal results by providing an objective metric of activity map quality. This research tests how sample size, age, or gender-specific templates, and unilateral templates affect template matching results.
New Method: We used an fMRI database of 76 healthy subjects performing 7 tasks assessing motor, language, and working memory functions. Templates were created with varying numbers of subjects, genders, and ages. Individual subjects were compared to templates using leave-one-out cross validation. We also compared unilateral and bilateral templates.
Results: Increasing sample size improved template matches, with diminishing returns for larger sample sizes. Gender and age-specific templates increased correlations for some tasks, with age having a larger effect than gender. Generally, templates including all subjects provided the highest correlations, indicating that age and gender effects did not outweigh the benefits of larger sample sizes. Unilateral templates of the task-dominant hemisphere increased template correlations.
Conclusions: Age and gender affect templates, but the benefits depend on the database size. When the database is large enough, age and gender effects are beneficial. Unilateral templates enhance template matching, but practical benefits depend on the severity of neurological abnormalities in patients.
Competing Interests: Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Mathijs Raemaekers reports financial support was provided by ITEA (Eureka Cluster on software innovation). If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper
(Copyright © 2024. Published by Elsevier B.V.)
Databáze: MEDLINE
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