Enhancing therapeutic efficacy: In vivo mechanisms and biochemical effects of lycopene encapsulated in nanomicelles for acute inflammation and lipid metabolism.

Autor: Neves-Silva S; Brazilian Nuclear Energy Commission, Nuclear Engineering Institute, Laboratory of Nanoradiopharmacy and Synthesis of New Radiopharmaceuticals, Rio de Janeiro, 21941906, RJ, Brazil., Xavier-de-Britto I; Brazilian Nuclear Energy Commission, Nuclear Engineering Institute, Laboratory of Nanoradiopharmacy and Synthesis of New Radiopharmaceuticals, Rio de Janeiro, 21941906, RJ, Brazil., Gomes-da-Silva NC; Brazilian Nuclear Energy Commission, Nuclear Engineering Institute, Laboratory of Nanoradiopharmacy and Synthesis of New Radiopharmaceuticals, Rio de Janeiro, 21941906, RJ, Brazil., França ÁRS; Biophysics and Nanosystems Laboratory, Federal University of Maranhão, Department of Physics, São Luis, 65065690, MA, Brazil; Center of Sciences of Imperatriz, Federal University of Maranhão, Imperatriz, MA, Brazil., Pedrochi F; Center of Sciences of Imperatriz, Federal University of Maranhão, Imperatriz, MA, Brazil., Queiroz MN; Center of Sciences of Imperatriz, Federal University of Maranhão, Imperatriz, MA, Brazil., Moura-Silva J; Programa de Pós-Graduação em Biociências, Universidade do Estado do Rio de Janeiro, Brazil., Majerowicz D; Programa de Pós-Graduação em Biociências, Universidade do Estado do Rio de Janeiro, Brazil; Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Brazil; Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular, Brazil., Ricci-Junior E; Federal University of Rio de Janeiro, School of Pharmacy, Rio de Janeiro 21941900, RJ, Brazil., Ferreira TPT; Laboratory of Inflammation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil; Rio de Janeiro Innovation Network in Nanosystems for Health-NanoSAÚDE/FAPERJ, Rio de Janeiro, Brazil., E Silva Martins PMR; Laboratory of Inflammation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil; Rio de Janeiro Innovation Network in Nanosystems for Health-NanoSAÚDE/FAPERJ, Rio de Janeiro, Brazil., Cai Y; State Key Laboratory of Bioactive Molecules and Druggability Assessment/International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education (MOE) of China, Guangdong, China; Key Lab of Traditional Chinese Medicine Informatization/International Science and Technology Cooperation Base of Guangdong Province/School of Pharmacy, Jinan University, Guangzhou, China., Fechine PBA; Advanced Chemistry Materials Group (GQMat) - Analytical Chemistry and Physical Chemistry Department, Federal Unversity of Ceará, - UFC, Campus do Pici, CP 12100, 60451-970 Fortaleza, CE, Brazil., Alencar LMR; Biophysics and Nanosystems Laboratory, Federal University of Maranhão, Department of Physics, São Luis, 65065690, MA, Brazil; Center of Sciences of Imperatriz, Federal University of Maranhão, Imperatriz, MA, Brazil., Sant'anna C; National Institute of Metrology, Quality and Technology, Av. Nossa Sra. das Graças, 50 - Xerém, Duque de Caxias, RJ, 25250-020, Brazil., Santos-Oliveira R; Brazilian Nuclear Energy Commission, Nuclear Engineering Institute, Laboratory of Nanoradiopharmacy and Synthesis of New Radiopharmaceuticals, Rio de Janeiro, 21941906, RJ, Brazil; National Institute of Metrology, Quality and Technology, Av. Nossa Sra. das Graças, 50 - Xerém, Duque de Caxias, RJ, 25250-020, Brazil; Rio de Janeiro State University, Laboratory of Radiopharmacy and Nanoradiopharmaceuticals, Rio de Janeiro, 23070200, RJ, Brazil. Electronic address: roliveira@ien.gov.br.
Jazyk: angličtina
Zdroj: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V [Eur J Pharm Biopharm] 2024 Nov 30, pp. 114585. Date of Electronic Publication: 2024 Nov 30.
DOI: 10.1016/j.ejpb.2024.114585
Abstrakt: This study focuses on developing, characterizing, and evaluating lycopene nanomicelles formulations for their therapeutic potential in treating acute inflammation and obesity. Lycopene, a hydrophobic carotenoid with potent antioxidant, anti-inflammatory, and anticancer properties, faces challenges in bioavailability due to its poor solubility. To address this, the study utilized nanocarrier systems like liposomes, nanoparticles, and nanoemulsions to enhance the solubility, stability, and bioavailability of lycopene. The lycopene nanomicelles demonstrated significant anti-inflammatory and anticancer activities through multiple mechanisms. It inhibited the NF-κB pathway, reducing the expression of pro-inflammatory mediators, and modulated apoptotic pathways, leading to increased apoptosis and reduced cell proliferation in cancer cells. Furthermore, lycopene enhanced phase II detoxifying enzymes activity, interfered with gap junction communication, and potentially improved DNA repair mechanisms, contributing to its anticancer efficacy. In vivo studies revealed that lycopene nanomicelles effectively reduced leukocyte and neutrophil counts in an acute inflammation model, especially at higher doses, highlighting its potential as a nanodrug for inflammation management. However, the study found no significant alteration in triglyceride levels, indicating a need for further investigation into the effects of lycopene and its nanostructured forms on lipid metabolism. Biochemical analyses showed variations in liver enzyme levels, suggesting protective effects on the liver but also indicating potential pancreatic activity or stress and low glucose levels. These findings underscore the necessity for comprehensive safety evaluations. Overall, this research underscores the promising therapeutic applications of lycopene nanomicelles in inflammation and cancer while emphasizing the importance of addressing safety and metabolic effects for effective clinical translation.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024. Published by Elsevier B.V.)
Databáze: MEDLINE
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