Defining the extracellular matrix in non-cartilage soft-tissues in osteoarthritis: a systematic review.

Autor:	Raza IGA; Medical Sciences Division, University of Oxford, Oxford, UK., Snelling SJB; Botnar Institute for Musculoskeletal Sciences, Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK., Mimpen JY; Botnar Institute for Musculoskeletal Sciences, Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.
Jazyk:	angličtina
Zdroj:	Bone & joint research [Bone Joint Res] 2024 Dec 03; Vol. 13 (12), pp. 703-715. Date of Electronic Publication: 2024 Dec 03.
DOI:	10.1302/2046-3758.1312.BJR-2024-0020.R1
Abstrakt:	Aims: Extracellular matrix (ECM) is a critical determinant of tissue mechanobiology, yet remains poorly characterized in joint tissues beyond cartilage in osteoarthritis (OA). This review aimed to define the composition and architecture of non-cartilage soft joint tissue structural ECM in human OA, and to compare the changes observed in humans with those seen in animal models of the disease. Methods: A systematic search strategy, devised using relevant matrix, tissue, and disease nomenclature, was run through the MEDLINE, Embase, and Scopus databases. Demographic, clinical, and biological data were extracted from eligible studies. Bias analysis was performed. Results: A total of 161 studies were included, which covered capsule, ligaments, meniscus, skeletal muscle, synovium, and tendon in both humans and animals, and fat pad and intervertebral disc in humans only. These studies covered a wide variety of ECM features, including individual ECM components (i.e. collagens, proteoglycans, and glycoproteins), ECM architecture (i.e. collagen fibre organization and diameter), and viscoelastic properties (i.e. elastic and compressive modulus). Some ECM changes, notably calcification and the loss of collagen fibre organization, have been extensively studied across osteoarthritic tissues. However, most ECM features were only studied by one or a few papers in each tissue. When comparisons were possible, the results from animal experiments largely concurred with those from human studies, although some findings were contradictory. Conclusion: Changes in ECM composition and architecture occur throughout non-cartilage soft tissues in the osteoarthritic joint, but most of these remain poorly defined due to the low number of studies and lack of healthy comparator groups. Competing Interests: J. Y. Mimpen reports grants for this study from Versus Arthritis (22873), the National Institute for Health Research Oxford Biomedical Research Centre, and the Chan-Zuckerberg Initiative (CZIF2019-002426). J. Y. Mimpen also reports an Oxford University Medical Sciences Division Pump-priming grant, unrelated to this study. S. J. B. Snelling reports grant support for salary during the timeframe of this study from the Chan-Zuckerberg Initiative and the National Institute for Health Research Oxford Biomedical Research Centre. (© 2024 Raza et al.)
Databáze:	MEDLINE
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