An Insight into the Role of IL-10 and Foamy Macrophages in Infectious Diseases.

Autor:	Steffy K; Laboratory of Molecular Cell Biology, BRIC-Centre for DNA Fingerprinting and Diagnostics, Uppal, Hyderabad, Telangana, India., Ahmed A; Laboratory of Molecular Cell Biology, BRIC-Centre for DNA Fingerprinting and Diagnostics, Uppal, Hyderabad, Telangana, India.; Laboratory of Human Immunology, Division of Infectious Diseases, St. John's Research Institute, Bengaluru, India., Srivastava S; Laboratory of Molecular Cell Biology, BRIC-Centre for DNA Fingerprinting and Diagnostics, Uppal, Hyderabad, Telangana, India.; Research and Development Office, Ashoka University, Rajiv Gandhi Education City, Sonipat, Haryana, India., Mukhopadhyay S; Laboratory of Molecular Cell Biology, BRIC-Centre for DNA Fingerprinting and Diagnostics, Uppal, Hyderabad, Telangana, India.
Jazyk:	angličtina
Zdroj:	Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2024 Dec 15; Vol. 213 (12), pp. 1729-1737.
DOI:	10.4049/jimmunol.2400033
Abstrakt:	Dysregulation of lipid homeostasis causes the deposition of lipids in the form of tiny droplets within foamy macrophages (FMs). In FMs, host-derived lipids aid in survival of various intracellular pathogens leading to sustained infection. In several infectious diseases, the transformation of macrophages into a foamy phenotype is linked to the presence of high IL-10, a potent immune-modulatory cytokine. This review aims to understand the role of IL-10 in the signaling events that are crucial in generation of FMs and highlights how various intracellular pathogens targets the IL-10-FM axis for successful establishment of infections. The review also briefly discusses how the IL-10-FM axis can be a target for developing novel therapeutic strategies to prevent intracellular infections. (Copyright © 2024 by The American Association of Immunologists, Inc.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu