Sarcopenia is associated with worse outcomes in patients with inflammatory bowel disease: insights from US national hospitalization data.

Autor:	Kohli I; Department of Public Health, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Thind N; Department of Medicine, Dayanand Medical College and Hospital, Ludhiana., Bhalla A; Department of Medicine, Punjab Institute of Medical Sciences, Jalandhar, Punjab, India., Attri A; Department of Medicine, Dayanand Medical College and Hospital, Ludhiana., Bhupal SS; Department of Medicine, Dayanand Medical College and Hospital, Ludhiana., Sohal A; Department of Hepatology, Liver Institute Northwest, Seattle, Washington., Yang J; Department of Gastroenterology and Hepatology, University of Texas - Medical Branch Galveston, Galveston, Texas, USA.
Jazyk:	angličtina
Zdroj:	European journal of gastroenterology & hepatology [Eur J Gastroenterol Hepatol] 2025 Jan 01; Vol. 37 (1), pp. 55-61. Date of Electronic Publication: 2024 Nov 27.
DOI:	10.1097/MEG.0000000000002852
Abstrakt:	Background: Inflammatory bowel disease (IBD) is an inflammatory disorder associated with significant morbidity and mortality. Recent studies have reported sarcopenia as a significant factor affecting the quality of life and outcomes of these patients. Methods: We used the National Inpatient Sample 2016-2020 to identify adult patients with IBD. The patients were stratified into two groups based on the presence of sarcopenia. Data were collected on patient demographics, hospital characteristics, and comorbidities. The outcomes studied were in-hospital mortality, sepsis, shock, ICU admission, and need for surgery. Multivariate logistic regression analysis was performed. Results: A total of 1 524 820 IBD hospitalizations were included. Of these, 209 615 (9%) were noted to have sarcopenia. Patients with sarcopenia had a higher incidence of in-hospital mortality (4.2% vs. 1.2%, P < 0.001), ICU admission (6.5% vs. 2.4%, P < 0.001), and need for abdominal surgery (6.5% vs. 3.5%, P < 0.001). After adjusting for confounders, the presence of sarcopenia was associated with higher odds of in-hospital mortality (adjusted odds ratio: 2.83, 95% confidence interval: 2.66-3.02, P < 0.001) and additional worse outcomes. Conclusion: Our study reports that the presence of sarcopenia was associated with an increased risk of death and the need for abdominal surgery. Preventative measures aimed at improving sarcopenia should be taken to prevent worse outcomes in this patient population. (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu