Platelet count and hypertension as indicators of height loss in the general population: A prospective study.

Autor: Shimizu Y; Department of General Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.; Epidemiology Section, Division of Public Health, Osaka Institute of Public Health, Osaka, Japan., Yamanashi H; Department of General Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.; Leading Medical Research Core Unit, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan., Noguchi Y; Department of Community Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan., Kawashiri SY; Leading Medical Research Core Unit, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.; Department of Community Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan., Arima K; Leading Medical Research Core Unit, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.; Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan., Nagata Y; Leading Medical Research Core Unit, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.; Department of Community Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan., Maeda T; Department of General Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.; Leading Medical Research Core Unit, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2024 Dec 02; Vol. 19 (12), pp. e0314527. Date of Electronic Publication: 2024 Dec 02 (Print Publication: 2024).
DOI: 10.1371/journal.pone.0314527
Abstrakt: Circulating CD34-positive cell count is inversely associated with height loss. It acts as an indicator of endothelial repair activity. In conjunction with CD34-positive cells, platelets contribute to endothelial repair. The presence of hypertension increases the demand for endothelial repair. Therefore, platelet count could be associated with height loss among individuals with hypertension. A retrospective study of 2,343 individuals aged 40 to 79 years was conducted. Height loss was defined as being in the highest quartile of annual height decrease (1.6 mm/year for men and 2.0 mm/year for women). A significant inverse association between platelet count and height loss was observed only among participants with hypertension. After adjusting for known cardiovascular risk factors, the odds ratio (95% confidence interval) for height loss per 1 standard deviation increment in platelet count (5.09×104/μL for men and 5.03×104/μL for women) was 0.83 (0.70, 0.98) for participants with hypertension and 1.02 (0.90, 1.16) for participants without hypertension. Independent of known cardiovascular risk factors, platelets could prevent accelerated height loss among individuals with hypertension. Unlike CD34-positive cell count, platelet count and blood pressure, which are easy to assess in daily clinical practice, influence height loss.
Competing Interests: he authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright: © 2024 Shimizu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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