Effects of aging on complications following robot-assisted radical prostatectomy.

Autor: Koterazawa S; Department of Urology, Kyoto University School of Medicine, 54 Shougoinkawahara-Cho, Sakyo-Ku, Kyoto, 606-8507, Japan.; Department of Urology, Ijinkai Takeda General Hospital, Kyoto, Japan., Kubota M; Department of Urology, Kyoto University School of Medicine, 54 Shougoinkawahara-Cho, Sakyo-Ku, Kyoto, 606-8507, Japan., Sumiyoshi T; Department of Urology, Kyoto University School of Medicine, 54 Shougoinkawahara-Cho, Sakyo-Ku, Kyoto, 606-8507, Japan., Saito R; Department of Urology, Kyoto University School of Medicine, 54 Shougoinkawahara-Cho, Sakyo-Ku, Kyoto, 606-8507, Japan., Takaoka N; Department of Urology, Tenri Hospital, Nara, Japan., Hattori Y; Department of Urology, Kobe City Medical Center General Hospital, Hyogo, Japan., Shimizu Y; Department of Urology, Kobe City Nishi-Kobe Medical Center, Hyogo, Japan., Kanno T; Department of Urology, National Hospital Organization Kyoto Medical Center, Kyoto, Japan., Soda T; Department of Urology, Tazuke Kofukai, Medical Research Institute, Kitano Hospital, Osaka, Japan., Okada Y; Department of Urology, Kyoto-Katsura Hospital, Kyoto, Japan., Tsuchihashi K; Department of Urology, Japanese Red Cross Otsu Hospital, Shiga, Japan., Sekine Y; Department of Urology, Akita University Graduate School of Medicine, Akita, Japan., Negoro H; Department of Urology, University of Tsukuba, Ibaraki, Japan., Kurahashi R; Department of Urology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan., Shimatani K; Department of Urology, Hyogo Medical University, Hyogo, Japan., Sawada A; Department of Urology, Miyazaki University, Miyazaki, Japan., Akamatsu S; Department of Urology, Nagoya University, Aichi, Japan., Goto T; Department of Urology, Kyoto University School of Medicine, 54 Shougoinkawahara-Cho, Sakyo-Ku, Kyoto, 606-8507, Japan. goto@kuhp.kyoto-u.ac.jp., Kobayashi T; Department of Urology, Kyoto University School of Medicine, 54 Shougoinkawahara-Cho, Sakyo-Ku, Kyoto, 606-8507, Japan. selecao@kuhp.kyoto-u.ac.jp.
Jazyk: angličtina
Zdroj: International journal of clinical oncology [Int J Clin Oncol] 2024 Dec 02. Date of Electronic Publication: 2024 Dec 02.
DOI: 10.1007/s10147-024-02660-7
Abstrakt: Background: For prostate cancer (PCa) in the elderly, including patients ≥ 80 years, the safety of robot-assisted radical prostatectomy (RARP) is controversial. We aimed to evaluate the effect of aging on the postoperative complication rates after RARP.
Methods: This cohort study used a database of patients who had undergone RARP at 25 different institutes. We divided the cohort into four age groups (< 70, 70-74, 75-79, and ≥ 80 years). The complication rates after RARP in the 70-74, 75-79, and ≥ 80 year group were compared using the < 70 year group serving as the control group by applying the inverse probability of treatment weighting (IPTW)-adjusted regression analysis.
Results: A total of 8055 patients were evaluated. The postoperative complication rates were 8.8%, 9.7%, 9.6%, and 10.0% in the < 70, 71-74, 75-79, and ≥ 80 age groups, respectively. In IPTW-adjusted analyses, the risk of overall complications (< 70 vs. 70-74 year group: OR = 1.09 [95% CI 0.92-1.29]; < 70 vs. 75-79 year group: OR = 1.09 [95% CI 0.88-1.37], and < 70 vs. ≥ 80 year group: OR = 2.21 [95% CI 0.92-5.32]) did not change with increasing age. There was no significant increase in risk for any complication category, such as bowel dysfunction, symptomatic lymphocele, or bacterial infection, between the < 70 and ≥ 80 age groups.
Conclusion: Our findings showed that, in appropriately selected patients, the risk of complications after RARP did not increase with age, even at 75 or 80 years.
Competing Interests: Declarations. Conflict of interest: The authors declare that they have no conflict of interest. Data availability: Data will be provided by the corresponding author upon a reasonable request. Ethical approval: The present study was conducted according to the ethical standards established by the Declaration of Helsinki. The Institutional Review Board of Kyoto University Hospital approved this study and the Common Study Database (R 3168). Informed consent: The need for informed consent was waived because of the retrospective design of the study.
(© 2024. The Author(s) under exclusive licence to Japan Society of Clinical Oncology.)
Databáze: MEDLINE
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