Progressive Supranuclear Palsy in India: Past, Present, and Future.

Autor:	Raju S; Department of Neurology, Manipal Hospital, Hebbal, Bengaluru, Karnataka, India., Shetty K; Department of Neurology, Mazumdar Shaw Medical Center, Narayana Health City, Bengaluru, Karnataka, India., Sahoo L; Department of Neurology, Institute of Medical Sciences and SUM Hospital, Bhubaneswar, Odisha, India., Paramanandam V; Department of Neurology, Apollo Hospitals, Greams Road, Chennai, Tamil Nadu, India., Iyer JM; Departments of Molecular and Cellular Biology and Statistics, Harvard University, Cambridge MA, USA., Bowmick S; Department of Neurology, Vadodara Institute of Neurological Sciences, Vadodara, Gujarat, India., Desai S; Department of Neurology, Shree Krishna Hospital Pramukhswami Medical College Bhaikaka University, Karamsad Anand, Gujarat, India., Joshi D; Department of Neurology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India., Kumar N; Department of Neurology, All India Institute of Medical Sciences, Bibinagar, Telangana, India., Mehta S; Department of Neurology, Post Graduate Institute of Medical Education and Research, Chandigarh, India., Kandadai RM; Department of Neurology, Citi Neuro Center, Hyderabad, Telangana, India., Wadia P; Movement Disorder Clinic, Department of Neurology, Jaslok Hospital and Research Centre, Mumbai, Maharashtra, India., Biswas A; Department of Neurology, Bangur Institute of Neurosciences and Institute of Post Graduate Medical Education and Research, Kolkata, West Bengal, India., Garg D; Department of Neurology, All India Institute of Medical Sciences, New Delhi, India., Agarwal P; Gleneagles Hospital, Mumbai and King Edward Memorial Hospital, Mumbai, Maharashtra, India., Krishnan S; Department of Neurology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, India., Ganguly J; Department of Neurology, Institute of Neurosciences Kolkata, Kolkata, West Bengal, India., Shah H; Department of Neurology, Jivraj Mehta Hospital, Ahmedabad, Gujarat, India., Chandarana M; Health 1 Super Specialty Hospitals, Ahmedabad, Gujarat, India., Kumar H; Department of Neurology, Institute of Neurosciences Kolkata, Kolkata, West Bengal, India., Borgohain R; Department of Neurology, Citi Neuro Center, Hyderabad, Telangana, India., Ramprasad VL; Department of Genetics, MedGenome Labs Pvt Ltd, Bengaluru, Karnataka, India., Kukkle PL; Department of Movement Disorders, Parkinson's Disease and Movement Disorders Clinic, Bengaluru, Karnataka, India.
Jazyk:	angličtina
Zdroj:	Annals of Indian Academy of Neurology [Ann Indian Acad Neurol] 2024 Dec 02. Date of Electronic Publication: 2024 Dec 02.
DOI:	10.4103/aian.aian_515_24
Abstrakt:	Abstract: Progressive supranuclear palsy (PSP) has emerged as a key area of interest among researchers worldwide, including those in India, who have actively studied the disorder over the past several decades. This review meticulously explores the extensive range of Indian research on PSP up to the present and offers insights into both current initiatives and potential future directions for managing PSP within the region. Historical research contributions have spanned 80 publications from 1974 to 2023, encompassing diverse themes from clinical phenotyping and historical analysis to isolated investigative studies and therapeutic trials. Traditionally, these studies have been conducted in single centers or specific departments, involving a broad range of recruitment numbers. The most frequently encountered phenotype among these studies is PSP-Richardson's syndrome, with patients typically presenting at an average age of 64 years, alongside various other subtypes. Recently, there has been a significant shift toward more collaborative research models, moving from isolated, center-based studies to expansive, multicentric, and pan India projects. A prime example of this new approach is the PAn India Registry for PSP (PAIR-PSP) project, which represents a comprehensive effort to uniformly examine the demographic, clinical, and genetic facets of PSP across India. Looking ahead, there is a critical need for focused research on unraveling genetic insights, identifying risk factors, and developing effective treatment interventions and preventive models. Given its vast population, India's role in advancing our understanding of PSP and other tauopathies could be pivotal, and this work reflects the work on PSP in India till now. (Copyright © 2024 Annals of Indian Academy of Neurology.)
Databáze:	MEDLINE
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