Is there a role of cytoreductive surgery with HIPEC in recurrent ovarian granulosa cell tumors? An Indian cancer center experience with review of literature.

Autor:	Ray M; Department of Surgical Oncology, All India Institute of Medical Sciences, New Delhi, India., Jayraj AS; Department of Gynaecologic Oncology, All India Institute of Medical Sciences, New Delhi, India., Dhall K; Department of Surgical Oncology, All India Institute of Medical Sciences, New Delhi, India., Pandey R; Department of Radiation Oncology, All India Institute of Medical Sciences, New Delhi, India., Deo SVS; Department of Surgical Oncology, All India Institute of Medical Sciences, New Delhi, India.
Jazyk:	angličtina
Zdroj:	Indian journal of cancer [Indian J Cancer] 2024 Jan 01; Vol. 61 (1), pp. 156-165. Date of Electronic Publication: 2024 May 02.
DOI:	10.4103/ijc.ijc_1454_21
Abstrakt:	Background: Granulosa cell tumors of the ovary represent the most common sex-cord stromal tumors. Though characterized by an indolent course and a good five-year survival rate, they tend to have late recurrences and subsequent poorer survival. The role of hyperthermic intraperitoneal chemotherapy (HIPEC) in women with recurrent granulosa cell tumors with peritoneal dissemination has not been well defined. Methods: All patients with adult or juvenile type granulosa cell tumors who underwent cytoreductive surgery with HIPEC with 70 mg/m2 of cisplatin for 60 minutes over a period of four years were retrospectively evaluated. We also performed a review of the literature on similar cases reported. Results: We identified eight patients with recurrent adult granulosa cell tumors (AGCT) who fulfilled our inclusion criteria. The mean operative duration was 340 minutes, inclusive of the duration of HIPEC. Fifty percent of patients suffered from postoperative morbidity. Grade 4 morbidity was observed in one patient. At a median follow-up of 35 months, four patients experienced disease recurrence. The median disease-free survival was 10 months (range: 6-31 months) and the median overall survival was 11.5 months (range: 7-40 months). Conclusion: Cytoreductive surgery (CRS) and HIPEC provides a unique opportunity for treating peritoneal dissemination in patients with recurrent ovarian AGCTs. This procedure is well tolerated with acceptable morbidity. Prospective studies are warranted to further elucidate the efficacy of this novel therapeutic approach in recurrent ovarian granulosa cell tumors. (Copyright © 2024 Copyright: © 2024 Indian Journal of Cancer.)
Databáze:	MEDLINE
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