The burden of subclinical TB in Nigeria.

Autor:	Odume B; KNCV Tuberculosis Foundation, Abuja, Nigeria., Ogbudebe C; KNCV Tuberculosis Foundation, Abuja, Nigeria., Mukadi Y; United States Agency for International Development (USAID), Washington, DC, USA., Dim C; College of Medicine, University of Nigeria, Ituku-Ozalla, Nigeria., Chukwu E; KNCV Tuberculosis Foundation, Abuja, Nigeria., Chukwuogo O; KNCV Tuberculosis Foundation, Abuja, Nigeria., Useni S; KNCV Tuberculosis Foundation, Abuja, Nigeria., Nwokoye N; KNCV Tuberculosis Foundation, Abuja, Nigeria., Sheshi M; KNCV Tuberculosis Foundation, Abuja, Nigeria., Nongo D; USAID, Abuja, Nigeria., Eneogu R; USAID, Abuja, Nigeria., Ihesie A; USAID, Abuja, Nigeria., Ubochioma E; National TB, Leprosy and Buruli Ulcer Control Programme, Federal Ministry of Health Nigeria, Abuja, Nigeria., Anyaike C; National TB, Leprosy and Buruli Ulcer Control Programme, Federal Ministry of Health Nigeria, Abuja, Nigeria.
Jazyk:	angličtina
Zdroj:	Public health action [Public Health Action] 2024 Dec 01; Vol. 14 (4), pp. 181-185. Date of Electronic Publication: 2024 Dec 01 (Print Publication: 2024).
DOI:	10.5588/pha.24.0038
Abstrakt:	Setting: This study is a retrospective review of a large-scale systematic TB screening project conducted in six states of Nigeria. Objective: To determine the magnitude and characteristics of subclinical TB and the relative contributions of bacteriological versus clinical diagnosis in its identification in Nigeria. Design: Data were retrospectively analysed from six states of Nigeria, where parallel screening with any TB symptoms and chest X-ray (CXR) with artificial intelligence (AI) was used for active case finding. Diagnosis of TB among presumptive was confirmed using either bacteriological tests or clinical review of CXR. Results: Out of 8,516 presumptive identified during the project, 172 (2.0%) had no TB symptoms (males: 73.8%, females: 26.2%). The overall prevalence of TB among all presumptive was 21.9% ( n = 1,867), including 62 (3.3%) subclinical TB and 1,805 (97.3%) active TB cases. The proportion of clinical diagnosis using CXR was significantly higher in the subclinical TB group than in the active TB group (79.0% vs. 63.5%; P = 0.012, OR = 2.2, 95% CI 1.17-4.03). Conclusion: Subclinical TB contributed 3.3% of the large TB burden in this study (22 per 100 presumptive). These cases would have been missed if only symptom-based TB screening had been employed. (© 2024 The Authors.)
Databáze:	MEDLINE
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