Spontaneous Tumor Lysis Syndrome in the Setting of Pancreatic Adenocarcinoma.
| Autor: | Coyne BM; Internal Medicine, George Washington University School of Medicine and Health Sciences, Washington, USA., Ishaq SM; Medicine, Sinai Hospital of Baltimore, Baltimore, USA., Coyne CJ; Biology, University of California Riverside, Riverside, USA., Shiflett BS; Medicine, Sinai Hospital of Baltimore, Baltimore, USA., Birnbaum JT; Internal Medicine, Sinai Hospital of Baltimore, Baltimore, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Cureus [Cureus] 2024 Oct 30; Vol. 16 (10), pp. e72735. Date of Electronic Publication: 2024 Oct 30 (Print Publication: 2024). |
| DOI: | 10.7759/cureus.72735 |
| Abstrakt: | Tumor lysis syndrome (TLS) is the destruction of tumor cells, causing the release of intracellular contents, including but not limited to uric acid, phosphate, and potassium. This can manifest with significant physiologic abnormalities, such as life-threatening acute kidney injury. Although TLS is usually caused by the initiation of cytotoxic chemotherapy, it may also occur spontaneously, particularly in high-grade malignancies with high tumor burden and/or rapid cell turnover. Here, we present a case of spontaneous TLS in a patient with early-phase pancreatic cancer diagnosis and possible signs of metastasis. Additionally, we provide a comprehensive review of the current literature regarding this phenomenon. In the present case, our patient was stabilized using aggressive intravenous hydration and pharmacotherapy. This case report adds to the slowly growing literature surrounding the diagnosis and management of spontaneous TLS in pancreatic adenocarcinomas. Competing Interests: Human subjects: Consent for treatment and open access publication was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. (Copyright © 2024, Coyne et al.) |
| Databáze: | MEDLINE |
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