Bilateral Sequential Non-arteritic Anterior Ischaemic Optic Neuropathy (NA-AION) Presumed Secondary to 5-Fluorouracil (5-FU): A Case Report and Literature Review.
| Autor: | Agarwal P; Ophthalmology, Warrington and Halton Hospitals NHS Foundation Trust, Warrington, GBR., Khera M; Ophthalmology, Warrington and Halton Hospitals NHS Foundation Trust, Warrington, GBR. |
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| Jazyk: | angličtina |
| Zdroj: | Cureus [Cureus] 2024 Oct 31; Vol. 16 (10), pp. e72754. Date of Electronic Publication: 2024 Oct 31 (Print Publication: 2024). |
| DOI: | 10.7759/cureus.72754 |
| Abstrakt: | Bilateral successive anterior ischaemic optic neuropathy (AION) episodes are uncommon occurrences with a short list of differential diagnoses. We present the case of a 75-year-old male who developed bilateral consecutive non-arteritic AION after commencing 5-fluorouracil (5-FU) chemotherapy. The case report describes a temporal sequence of events with a halt in the progression of signs and symptoms upon cessation of treatment with this agent. Our patient demonstrated preexisting cardiovascular risk factors that were medically well controlled, as evidenced by laboratory results and blood pressure measurements. We reaffirm the current evidence that postulates an association between 5-FU use and arterial vasospasm in blood vessels predisposed to narrowing resulting in prolonged ischaemia to the optic nerve head. Competing Interests: Human subjects: Consent for treatment and open access publication was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. (Copyright © 2024, Agarwal et al.) |
| Databáze: | MEDLINE |
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