ABO blood type is not a risk factor of outcome in aneurysmal subarachnoid hemorrhage patients.

Autor: Wang R; Department of Neurosurgery, West China Hospital, Sichuan University, No.37, Guoxue Alley, Chengdu, 610041, Sichuan, China., Zhang J; Department of Neurosurgery, West China Hospital, Sichuan University, No.37, Guoxue Alley, Chengdu, 610041, Sichuan, China., Xu J; Department of Neurosurgery, West China Hospital, Sichuan University, No.37, Guoxue Alley, Chengdu, 610041, Sichuan, China. xujg@scu.edu.cn., He M; Department of Critical Care Medicine, West China Hospital, Sichuan University, No.37, Guoxue Alley, Chengdu, 610041, Sichuan, China. hemin19910306@wchscu.cn.
Jazyk: angličtina
Zdroj: European journal of medical research [Eur J Med Res] 2024 Dec 02; Vol. 29 (1), pp. 574. Date of Electronic Publication: 2024 Dec 02.
DOI: 10.1186/s40001-024-02143-5
Abstrakt: Background: The association between ABO blood types and outcome of aneurysm subarachnoid hemorrhage (aSAH) has not reached a conclusion. This study was performed to testify the difference of outcome between ABO blood types.
Methods: 663 aSAH patients hospitalized in the West China hospital were enrolled. The association between ABO blood types and outcomes including mortality and delayed cerebral ischemia (DCI) was verified by the univariate and multivariate logistic regression. Glasgow Outcome Score (GOS) at discharge, length of ICU stay, length of hospital stay were also compared between different ABO blood types.
Results: 663 aSAH patients were divided into four groups according to their ABO blood types: AB type (46, 6.9%), A type (211, 31.8%), B type (169, 25.4%),O type (237, 35.7%). The GCS, WFNS, Hunt Hess, modified Fisher, aneurysm location and incidence of intraventricular hemorrhage did not show different distribution among ABO blood types. Among four coagulation indexes, only the activated partial thromboplastin time (APTT) showed different distribution among ABO blood types (p < 0.001). The AB group had the lowest level of APTT while O group had the highest level of APTT. Outcomes including delayed cerebral ischemia, mortality, GOS, length of ICU stay, and length of hospital stay did not show any significant differences among ABO types. Univariate logistic regression showed the ABO blood type was not associated with the development of DCI (p = 0.654) and the mortality (p = 0.430). The multivariate logistic regression showed ABO blood types were still not associated with DCI and mortality after adjusting confounding effects of significant risk factors.
Conclusions: The ABO blood type is not associated with the prognosis of aSAH patients. ABO blood types may not be helpful on risk stratification of aSAH.
Competing Interests: Declarations. Ethics approval and consent to participate: This study was approved by the ethics committee of West China hospital (2021–1684) and conducted based on the Declaration of Helsinki. Informed consent forms of each patient for joining observational study were regularly signed by patients themselves or their legally authorized representatives once patients admitted to our hospital. Consent for publication: This study does not contain data from any individual person. Competing interests: The authors declare no competing interests.
(© 2024. The Author(s).)
Databáze: MEDLINE
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