BCPT perspectives on studies involving natural products, traditional Chinese medicine and systems pharmacology.

Autor: Tveden-Nyborg P; Section of Preclinical Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Yang B; Department of Pharmacology, Peking University, China., Simonsen U; Department of Biomedicine, Aarhus University, Aarhus, Denmark., Lykkesfeldt J; Section of Preclinical Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Jazyk: angličtina
Zdroj: Basic & clinical pharmacology & toxicology [Basic Clin Pharmacol Toxicol] 2024 Dec; Vol. 135 (6), pp. 782-785. Date of Electronic Publication: 2024 Dec 01.
DOI: 10.1111/bcpt.14109
Abstrakt: Natural products constitute a vast source of bioactive compounds with the potential of providing valuable insight for future medicines. However, from a pharmacological perspective, natural product studies are also often accompanied by serious limitations due to, for example, the complex nature of biological extracts, the challenge of reproducibly characterizing the extract and providing an exhaustive list of constituents and, consequently, the difficulties in linking the observed pharmacological effects to specific chemical entities. The present paper discusses the major challenges of studies with natural products and provides a guideline to be followed by authors submitting research findings involving data from natural products, and their derivatives, to Basic & Clinical Pharmacology & Toxicology.
(© 2024 Nordic Association for the Publication of BCPT (former Nordic Pharmacological Society). Published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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