Dietary exposure to mixtures of chemicals in the first year of life and allergic and respiratory diseases up to 8 years in the French EDEN mother-child cohort.

Autor: Ghozal M; Université Paris Cité and Université Sorbonne Paris Nord, Inserm, INRAE, Centre for Research in Epidemiology and StatisticS (CRESS), Paris, France. Electronic address: manel.ghozal@inserm.fr., Delvert R; Université Paris-Saclay, UVSQ, Université Paris-Sud, Inserm, Équipe d'Épidémiologie Respiratoire Intégrative, CESP, 94805, Villejuif, France., Adel-Patient K; Université Paris-Saclay, CEA, INRAE, MTS, Gif-sur-Yvette, France., Tafflet M; Université Paris Cité and Université Sorbonne Paris Nord, Inserm, INRAE, Centre for Research in Epidemiology and StatisticS (CRESS), Paris, France., Annesi-Maesano I; Institute Desbrest of Epidemiology and Public Health (IDESP), Montpellier University and INSERM, Montpellier, France., Crépet A; Anses, French Agency for Food, Environmental and Occupational Health and Safety, Risk Assessment Department, Methodology and Studies Unit, Maisons-Alfort, France., Sirot V; Anses, French Agency for Food, Environmental and Occupational Health and Safety, Risk Assessment Department, Methodology and Studies Unit, Maisons-Alfort, France., Charles MA; Université Paris Cité and Université Sorbonne Paris Nord, Inserm, INRAE, Centre for Research in Epidemiology and StatisticS (CRESS), Paris, France., Heude B; Université Paris Cité and Université Sorbonne Paris Nord, Inserm, INRAE, Centre for Research in Epidemiology and StatisticS (CRESS), Paris, France., Kadawathagedara M; Université Paris Cité and Université Sorbonne Paris Nord, Inserm, INRAE, Centre for Research in Epidemiology and StatisticS (CRESS), Paris, France., de Lauzon-Guillain B; Université Paris Cité and Université Sorbonne Paris Nord, Inserm, INRAE, Centre for Research in Epidemiology and StatisticS (CRESS), Paris, France. Electronic address: blandine.delauzon@inserm.fr.
Jazyk: angličtina
Zdroj: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2024 Nov 29; Vol. 196, pp. 115167. Date of Electronic Publication: 2024 Nov 29.
DOI: 10.1016/j.fct.2024.115167
Abstrakt: Exposure to environmental chemicals has been associated with higher risk of childhood allergies. This study aimed to examine the association between infant's dietary exposure to mixtures of chemicals and allergic and respiratory multimorbidity in childhood. Dietary exposures were assessed at 8 and 12 months in 724 and 745 children of the EDEN cohort. Allergic and respiratory multimorbidity clusters were identified using latent class analyses. Associations between dietary exposure to mixtures of chemicals and allergic clusters were assessed by adjusted multinomial logistic regressions. At 8 months, higher exposure to a mixture of furans, trace elements, dioxins and PAHs was positively associated with the "asthma only" cluster, while moderate exposure to a mixture of PAHs, pesticides, PCBs and acrylamide was negatively associated with this cluster. A mixture of PCBs and BFRs was positively associated with the "multi-morbidity" cluster. Exposure to a mixture of pesticides and trace elements was positively associated with the "allergy without asthma" cluster. At 12-months, higher exposure to a mixture of trace elements and pesticides was positively associated with "multi-morbidity" cluster. The differences in findings between the two ages suggest the need for further studies to explore this critical window of chemical exposure and its impact on children's health.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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