Dynamic modeling of antibody repertoire reshaping in response to viral infections.

Autor: Xu Z; Department of Life Science, Dezhou University, Dezhou 253023, China. Electronic address: xuzhaobin@dzu.edu.cn., Peng Q; State Key Laboratory of Subtropical Silviculture, Zhejiang A&F University, Hangzhou, 311300, China., Xu J; Department of Life Science, Dezhou University, Dezhou 253023, China., Zhang H; Department of Life Science, Dezhou University, Dezhou 253023, China., Song J; Department of Life Science, Dezhou University, Dezhou 253023, China., Wei D; State Key Laboratory of Microbial Metabolism, Shanghai-Islamabad-Belgrade Joint Innovation Center on Antibacterial Resistances, Joint International Research Laboratory of Metabolic & Developmental Sciences and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200030, China; Zhongjing Research and Industrialization Institute of Chinese Medicine, Zhongguancun Scientific Park, Meixi, Nanyang, Henan, 473006, China; Peng Cheng National Laboratory, Vanke Cloud City Phase I Building 8, Xili Street, Nashan District, Shenzhen, Guangdong, 518055, China., Zeng Q; Department of Life Science, Dezhou University, Dezhou 253023, China.
Jazyk: angličtina
Zdroj: Computers in biology and medicine [Comput Biol Med] 2025 Jan; Vol. 184, pp. 109475. Date of Electronic Publication: 2024 Dec 01.
DOI: 10.1016/j.compbiomed.2024.109475
Abstrakt: For decades, research has largely focused on the generation of high-affinity, antigen-specific antibodies during viral infections. This emphasis has made it challenging for immunologists to systematically evaluate the mechanisms initiating humoral immunity in specific immune responses. In this study, we employ ordinary differential equations (ODE) to investigate the dynamic reshaping of the entire antibody repertoire in response to viral infections. Our findings demonstrate that the host's antibody atlas undergoes significant restructuring during these infections by the selective expansion of antibody pools with strong binding activity. The simulation results indicate that the ELISA (Enzyme-Linked Immunosorbent Assay) outcomes do not directly reflect the levels of specific neutralizing antibodies, but rather represent a quantitative response of the reshaped antibody repertoire following infection. Our model transcends traditional theories of immune memory, providing an explanation for the sustained presence of specific antibodies in the human body in long term. Additionally, our model extends to explore the mechanistic basis of the original antigenic sin, providing practical applications of our framework. One important application of this model is that it indicates that antibodies with a faster forward binding rate are more effective in preventing and treating associated viral infections compared to those with higher binding affinity.
Competing Interests: Declaration of competing interest We know of no conflicts of interest associated with this publication, and there has been no significant financial support for this work that could have influenced its outcome. As Corresponding Author, I confirm that the manuscript has been read and approved for submission by all the named authors. All authors declare no conflict of interest.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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