Differential bone calcium retention with the use of oral versus vaginal hormonal contraception: A randomized trial using calcium-41 radiotracer .

Autor: Ricker EA; Women's Health and Exercise Laboratory, Department of Kinesiology, College of Health and Human Development, Pennsylvania State University, University Park, PA, USA. Electronic address: emily.ricker.ctr@usuhs.edu., De Souza MJ; Women's Health and Exercise Laboratory, Department of Kinesiology, College of Health and Human Development, Pennsylvania State University, University Park, PA, USA., Stone MS; Department of Nutrition Science, Purdue University, West Lafayette, IN USA., Jackson GS; Department of Physics and Astronomy, Purdue University, West Lafayette, IN USA., McCabe GP; Department of Statistics, Purdue University, West Lafayette, IN USA., McCabe LD; Department of Nutrition Science, Purdue University, West Lafayette, IN USA., Weaver CM; Department of Nutrition Science, Purdue University, West Lafayette, IN USA.
Jazyk: angličtina
Zdroj: Contraception [Contraception] 2024 Nov 28, pp. 110778. Date of Electronic Publication: 2024 Nov 28.
DOI: 10.1016/j.contraception.2024.110778
Abstrakt: Objectives: This study aimed to assess if hormonal contraception administered orally (combined oral contraceptive pill, COC) or vaginally (contraceptive vaginal ring) differentially affected bone calcium retention in young females.
Study Design: Reproductive aged females (18-35yr) not using hormonal contraception were dosed with 50 nCi 41 Ca as CaCl 2 in 10ml of sterile saline (0.9%). Following an equilibration phase of ≥100 days and a baseline of 2 menstrual cycles, participants used COC and the ring for 2 cycles (49 days) each, in a randomized order, separated and followed by washouts of 2 menstrual cycles. 24hr urine samples were collected monthly during equilibration and every ~10 days during baseline, interventions, and washouts to assess bone calcium retention through accelerator mass spectrometry analysis of the 41 Ca:Ca ratio in urine. The effect of each contraception was determined by comparing 41 Ca:Ca measured during each contraception intervention to 41 Ca:Ca measured during the "control" (baseline and washout) phases using linear models and generalized linear mixed models.
Results: Eight reproductive aged females were studied. Compared with control phases (baseline and washouts), COC resulted in greater bone calcium retention (11.3%, 95% CI: 6.7%, 15.6%). The ring did not alter bone calcium retention (4.2%, 95% CI: -6.6%, 13.9%). COC produced a greater change in calcium retention than the ring (p=0.03).
Conclusion: Although many factors contribute to bone health, short-term COC improved bone calcium retention, suggesting a potential benefit of COC to bone in females. Conversely, the ring did not alter calcium retention, and may be neither beneficial nor deleterious for bone.
Clinical Trials Registration Number: ClinicalTrials.gov ID: NCT02367846 Date of registration: Jan 27, 2015.
Competing Interests: Declarations of interest None
(Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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