Systemic coordination of whole-body tissue remodeling during local regeneration in sea anemones.

Autor:	Cheung S; European Molecular Biology Laboratory (EMBL), Developmental Biology Unit, Heidelberg 69117, Germany., Bredikhin D; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg 69117, Germany; Division of Computational Genomics and Systems Genetics, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany., Gerber T; European Molecular Biology Laboratory (EMBL), Developmental Biology Unit, Heidelberg 69117, Germany; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg 69117, Germany., Steenbergen PJ; European Molecular Biology Laboratory (EMBL), Developmental Biology Unit, Heidelberg 69117, Germany., Basu S; European Molecular Biology Laboratory (EMBL), Developmental Biology Unit, Heidelberg 69117, Germany., Bailleul R; European Molecular Biology Laboratory (EMBL), Developmental Biology Unit, Heidelberg 69117, Germany., Hansen P; European Molecular Biology Laboratory (EMBL), Developmental Biology Unit, Heidelberg 69117, Germany., Paix A; European Molecular Biology Laboratory (EMBL), Developmental Biology Unit, Heidelberg 69117, Germany., Benton MA; European Molecular Biology Laboratory (EMBL), Developmental Biology Unit, Heidelberg 69117, Germany., Korswagen HC; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, the Netherlands., Arendt D; European Molecular Biology Laboratory (EMBL), Developmental Biology Unit, Heidelberg 69117, Germany., Stegle O; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg 69117, Germany; Division of Computational Genomics and Systems Genetics, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, Cambridgeshire, UK. Electronic address: oliver.stegle@embl.de., Ikmi A; European Molecular Biology Laboratory (EMBL), Developmental Biology Unit, Heidelberg 69117, Germany. Electronic address: aissam.ikmi@embl.de.
Jazyk:	angličtina
Zdroj:	Developmental cell [Dev Cell] 2024 Nov 27. Date of Electronic Publication: 2024 Nov 27.
DOI:	10.1016/j.devcel.2024.11.001
Abstrakt:	The complexity of regeneration extends beyond local wound responses, eliciting systemic processes across the entire organism. However, the functional relevance and coordination of distant molecular processes remain unclear. In the cnidarian Nematostella vectensis, we show that local regeneration triggers a systemic homeostatic response, leading to coordinated whole-body remodeling. Leveraging spatial transcriptomics, endogenous protein tagging, and live imaging, we comprehensively dissect this systemic response at the organismal scale. We identify proteolysis as a critical process driven by both local and systemic upregulation of metalloproteases. We show that metalloproteinase expression levels and activity scale with the extent of tissue loss. This proportional response drives long-range tissue and extracellular matrix movement. Our findings demonstrate the adaptive nature of the systematic response in regeneration, enabling the organism to maintain shape homeostasis while coping with a wide range of injuries. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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