The evidence base for rotavirus vaccination in India: Current status, future needs.

Autor: Bhat N; Center for Vaccine Innovation and Access, PATH, 2201 Westlake Avenue, Suite 200, Seattle, WA 98121, USA. Electronic address: nbhat@path.org., Vodicka E; Center for Vaccine Innovation and Access, PATH, 2201 Westlake Avenue, Suite 200, Seattle, WA 98121, USA., Clifford A; Center for Vaccine Innovation and Access, PATH, 455 Massachusetts Ave NW, Washington, DC 20001, USA., Ananth KB; Center for Vaccine Innovation and Access, PATH, 15th Floor, Dr. Gopal Das Bhawan, 28 Barakhamba Road, New Delhi 110001, India., Bavdekar A; KEM Hospital Research Centre, Vadu Rural Health Program, P.O. Vadu Budruk, Taluka Shirur, District Pune 412216, India., Roy AD; JSI India, Plot No.5 & 6, LSC Shopping Complex, Nelson Mandela Marg, Vasant Kunj, New Delhi 110070, India., Parashar U; Centers for Disease Control and Prevention, 1600 Clifton Rd. NE, Atlanta, GA 30333, USA., Tate J; Centers for Disease Control and Prevention, 1600 Clifton Rd. NE, Atlanta, GA 30333, USA., Haldar P; Former Advisor (RCH), Ministry of Health and Family Welfare, Government of India, Delhi, India., Kang G; Division of Gastrointestinal Sciences, The Wellcome Trust Research Laboratory, Christian Medical College, Vellore, Tamil Nadu 632004, India.
Jazyk: angličtina
Zdroj: Vaccine [Vaccine] 2024 Nov 29; Vol. 44, pp. 126551. Date of Electronic Publication: 2024 Nov 29.
DOI: 10.1016/j.vaccine.2024.126551
Abstrakt: Rotavirus is a leading cause of severe diarrheal disease in infants and young children worldwide. Vaccination offers the best protection against this disease, and two rotavirus vaccines were developed in India and included in its routine immunization program. The Government of India's decision to adopt this intervention was supported by a solid base of evidence from clinical trials, as well as substantial research regarding rotavirus disease burden and the potential health and economic value of immunization. Following program implementation, multiple studies were initiated, including three evaluations of effectiveness and several investigations regarding intussusception. These additional data regarding vaccine impact, safety, and delivery from post-introduction evaluations in conditions of real-world use will further strengthen and sustain the immunization program. This manuscript evaluates the status of existing and forthcoming evidence regarding rotavirus vaccination in India through a literature review and consultation with relevant stakeholders. Studies evaluating vaccine impact, effectiveness, safety, health economics, and acceptability, as well as operational and programmatic research, were included in the review. Overall, we found that the evidence base did not contain any major gaps. Nevertheless, additional smaller-scale research studies would be valuable in providing a more complete picture of rotavirus vaccine performance and benefit. Documentation of India's experience with rotavirus vaccines may provide lessons learned for other countries in the Asia region, where rotavirus disease burden remains high, yet vaccine adoption has been slow, as well as for countries worldwide that may be considering implementation of the Indian-made rotavirus vaccines.
Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Niranjan Bhat reports financial support was provided by Bill & Melinda Gates Foundation. Elisabeth Vodicka reports financial support was provided by Bill & Melinda Gates Foundation. Allison Clifford reports financial support was provided by Bill & Melinda Gates Foundation. Kanduri Balaji Ananth reports financial support was provided by Bill & Melinda Gates Foundation. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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