Innovative Pyrazole Hybrids: A New Era in Drug Discovery and Synthesis.

Autor: Bendi A; Innovation and Translational Research Hub (iTRH) & Department of Chemistry, Presidency University, Bangalore, Karnataka, India., Devi P; Department of Chemistry, Kurukshetra University, Kurukshetra, Haryana, India., Sharma H; Department of Chemistry, Kurukshetra University, Kurukshetra, Haryana, India., Yadav G; Department of Chemistry, Kurukshetra University, Kurukshetra, Haryana, India., Raghav N; Department of Chemistry, Kurukshetra University, Kurukshetra, Haryana, India., Pundeer R; Department of Chemistry, Indira Gandhi University, Meerpur, Rewari, Haryana, India., Afshari M; Department of Chemistry, Shoushtar Branch, Islamic Azad University, Shoushtar, Iran.
Jazyk: angličtina
Zdroj: Chemistry & biodiversity [Chem Biodivers] 2024 Nov 29, pp. e202402370. Date of Electronic Publication: 2024 Nov 29.
DOI: 10.1002/cbdv.202402370
Abstrakt: Heterocyclic compounds that include nitrogen and their derivatives have long been regarded as excellent sources of medicinal substances. Pyrazole is a compound with two nitrogen atoms and an aromatic structure. It has several uses and intricate stereochemistry arranged in a five-membered ring. The knowledge of different pyrazole derivatives and their range of physiological and pharmacological actions has grown significantly in recent years. The scientific community has recently increasingly focused on exploring the chemistry of various pyrazole hybrids due to their enhanced biological activities. This review investigates the chemistry of these diverse pyrazole hybrids, emphasizing their synthesis and their antidiabetic, antibacterial, anticancer, antimicrobial, antioxidant, and anti-inflammatory activities. Articles published from 2014 onward with an emphasis on the last 5 years are included in this review. This review is anticipated to be useful for future investigations and innovative concepts in the pursuit of designs for creating more promising hybrids of pyrazoles.
(© 2024 Wiley‐VHCA AG, Zurich, Switzerland.)
Databáze: MEDLINE
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