Co-occurrence of Loeys-Dietz syndrome with postural orthostatic tachycardia syndrome: A case series.

Autor: Boustany M; Gilbert and Rose-Marie Chagoury School of Medicine, Lebanese American University, Byblos, Lebanon; Lebanese American University Medical Center - Rizk Hospital, Beirut, Lebanon., Arvantaj A; Neurological Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, United States of America. Electronic address: Ali.Arvantaj@uhhospitals.com., Chémali KR; Neurological Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, United States of America; Department of Neurology, Case Western Reserve University School of Medicine, Cleveland, OH, United States of America.
Jazyk: angličtina
Zdroj: Autonomic neuroscience : basic & clinical [Auton Neurosci] 2024 Dec; Vol. 256, pp. 103220. Date of Electronic Publication: 2024 Nov 20.
DOI: 10.1016/j.autneu.2024.103220
Abstrakt: Loeys-Dietz syndrome (LDS) is a connective tissue disorder arising from mutations in the TGF- β signaling pathway. The spectrum of clinical manifestations is broad, and includes vascular, skeletal, and craniofacial abnormalities, along with joint hypermobility. No evidence of postural orthostatic tachycardia syndrome (POTS) in these patients has been reported. We report here a case series of patients with LDS presenting to the autonomic clinic and found to have POTS. Understanding the exact pathophysiology of this association requires further studies. Acknowledging the co-occurrence of these conditions is important to improve outcomes, and managing POTS in LDS patients necessitates an interdisciplinary approach.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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