GHRH and reproductive systems: Mechanisms, functions, and clinical implications.

Autor: Pérez-Gómez JM; Maimonides Institute for Biomedical Research of Córdoba (IMIBIC), IMIBIC Building. Av. Menéndez Pidal S/N. 14004, Cordoba, Spain.; Department of Cell Biology, Physiology, and Immunology, University of Córdoba, Cordoba, Spain.; Hospital Universitario Reina Sofía (HURS), Cordoba, Spain., Montero-Hidalgo AJ; Maimonides Institute for Biomedical Research of Córdoba (IMIBIC), IMIBIC Building. Av. Menéndez Pidal S/N. 14004, Cordoba, Spain.; Department of Cell Biology, Physiology, and Immunology, University of Córdoba, Cordoba, Spain.; Hospital Universitario Reina Sofía (HURS), Cordoba, Spain., Luque RM; Maimonides Institute for Biomedical Research of Córdoba (IMIBIC), IMIBIC Building. Av. Menéndez Pidal S/N. 14004, Cordoba, Spain. raul.luque@uco.es.; Department of Cell Biology, Physiology, and Immunology, University of Córdoba, Cordoba, Spain. raul.luque@uco.es.; Hospital Universitario Reina Sofía (HURS), Cordoba, Spain. raul.luque@uco.es.; Centro de Investigación Biomédica en Red de Fisiopatología de La Obesidad y Nutrición, (CIBERobn), Cordoba, Spain. raul.luque@uco.es.
Jazyk: angličtina
Zdroj: Reviews in endocrine & metabolic disorders [Rev Endocr Metab Disord] 2024 Nov 29. Date of Electronic Publication: 2024 Nov 29.
DOI: 10.1007/s11154-024-09931-8
Abstrakt: Growth hormone-releasing hormone (GHRH) has classically been considered a regulatory neuropeptide of the hypothalamic-pituitary system, which mediates its anabolic effects through hepatic GH/IGF-I axis. However, during the last decades it has been demonstrated that this key regulatory hormone may be produced in numerous peripheral tissues outside the central nervous system, participating in fundamental physiological functions through a complex balance between its purely endocrine action, and the recently local (autocrine/paracrine) discovered role. Among peripheral sites, its presence in the male and female reproductive systems stands out. In this review, we will first explore the role of the GHRH/GHRH-R hormone axis as a central player in the gonadal function; then, we will discuss available information regarding the presence of GHRH/GHRH-R and the potential physiological roles in reproductive systems of various species; and finally, we will address how reproductive system-related disorders-such as infertility problems, endometriosis, or tumor pathologies (including prostate, or ovarian cancer)-could benefit from hormonal interventions related to the manipulation of the GHRH axis.
Competing Interests: Declarations. Conflict of interest: The authors declare no competing interests.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
Externí odkaz: