[Multiparametric magnetic resonance imaging of the breast : What can we expect from the future?]

Autor: Prinz D; Division of Molecular and Structural Preclinical Imaging, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Wien, Österreich., Bartsch SJ; Division of Molecular and Structural Preclinical Imaging, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Wien, Österreich., Ehret V; Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Wien, Österreich., Friske J; Division of Molecular and Structural Preclinical Imaging, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Wien, Österreich., Pinker K; Division of Molecular and Structural Preclinical Imaging, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Wien, Österreich.; Division of Breast Imaging, Department of Radiology, Columbia University Vagelos College of Physicians and Surgeons, New York, USA., Helbich TH; Division of Molecular and Structural Preclinical Imaging, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Wien, Österreich. thomas.helbich@meduniwien.ac.at.
Jazyk: němčina
Zdroj: Radiologie (Heidelberg, Germany) [Radiologie (Heidelb)] 2024 Nov 29. Date of Electronic Publication: 2024 Nov 29.
DOI: 10.1007/s00117-024-01390-1
Abstrakt: Background: The combination of different MRI methods is described as multiparametric MRI (mpMRI) and plays a significant role in breast cancer diagnostics. Currently, mpMRI includes contrast-enhanced and diffusion-weighted MRI. For a more comprehensive characterization of the key processes involved in cancer development, additional MRI methods that capture functional processes at the cellular and molecular levels are necessary. In the context of preclinical studies, MRI methods that enable contrast-free evaluation of key processes at the metabolic and molecular levels are being developed for future clinical applications.
Objectives: What does multiparametric MRI in breast cancer look like in the future?
Methods: Systematic literature analysis focusing on preclinical research with regard to mpMRI as well as development and modification of noninvasive MRI methods.
Results: Some of the most promising MRI methods for the evaluation of breast cancer that can answer functional and metabolic questions are BOLD (blood oxygen level dependent), IVIM (intravoxel incoherent motion), DMI (deuterium metabolic imaging) and CEST (chemical exchange saturation transfer). A combination and, therefore, a multiparametric approach allows for a noninvasive differentiation of breast cancer subtypes and early detection of treatment response which is crucial for the future development of the disease.
Conclusion: Standardization of quantification methods as well as improvement and expansion of MRI methods enable such a multiparametric, functional, and metabolic evaluation of the tumor. Many of these are initially developed in preclinical settings before they can be translated into clinical practice.
Competing Interests: Einhaltung ethischer Richtlinien. Interessenkonflikt: K. Pinker gibt an, dass Sie Teil des Rednerbüros der European Society of Breast Imaging (EUSOBI) (aktiv), Bayer (beendet), Siemens Healthineers (beendet), DKD 2019 (beendet), Olea Medical (beendet), und Roche (beendet) ist und Beratungen für Genentech, Merantix Healthcare, AURA Health Technologies, Guerbet und Bayer durchführt. T.H. Helbich gibt an Teil des Rednerbüros der European Society of Breast Imaging (EUSOBI) (aktiv) zu sein und Kooperationen mit Bracco, Siemens Healthineers, Guerbet, Novomed, Bruker und BD hat. D. Prinz, S.J. Bartsch, V. Ehret und J. Friske geben an, dass kein Interessenkonflikt besteht. Alle nationalen Richtlinien zur Haltung und zum Umgang mit Labortieren wurden eingehalten und die notwendigen Zustimmungen der zuständigen Behörden liegen vor.
(© 2024. The Author(s).)
Databáze: MEDLINE
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