| Autor: |
Chandran M; Department of Bionanotechnology, Gachon University, Gyeonggi-do 13120, Republic of Korea. biovijaysaran@gmail.com., Chellasamy G; Department of Bionanotechnology, Gachon University, Gyeonggi-do 13120, Republic of Korea. biovijaysaran@gmail.com., Veerapandian M; Department of Bionanotechnology, Gachon University, Gyeonggi-do 13120, Republic of Korea. biovijaysaran@gmail.com., Dhanasekaran B; Department of Bionanotechnology, Gachon University, Gyeonggi-do 13120, Republic of Korea. biovijaysaran@gmail.com., Govindaraju S; Department of Bionanotechnology, Gachon University, Gyeonggi-do 13120, Republic of Korea. biovijaysaran@gmail.com., Yun K; Department of Bionanotechnology, Gachon University, Gyeonggi-do 13120, Republic of Korea. biovijaysaran@gmail.com. |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of materials chemistry. B [J Mater Chem B] 2024 Nov 29. Date of Electronic Publication: 2024 Nov 29. |
| DOI: |
10.1039/d4tb01818d |
| Abstrakt: |
Next-generation 2D materials, such as transition metal carbides and nitrides (MXenes), have received increasing attention owing to their physicochemical properties. In this study, we synthesized highly intense fluorescent materials, nitrogen-doped MXene quantum dots (N-MQDs) using an easy and less time-consuming microwave-assisted method. These N-MQDs are spherical, fluorescent, and highly sensitive materials, as confirmed by high-resolution transmission electron microscopy, atomic force microscopy, UV-visible, fluorescence, Fourier transform infrared spectroscopy, X-ray diffraction, Raman spectroscopy, zeta potential, and contact angle measurements. The N-MQDs were used as dual probes for the fluorescence and electrochemical sensing of neurotransmitter norepinephrine (NE-0.1 to 500 μM). The sensing strategy is based on the Förster resonance energy transfer acquired by the N-MQDs, leading to fluorescence quenching at 400 nm. A new emission peak at 500 nm with color changes and NE-to-NE quinone conversion in an electrochemical reaction. Fluorescence and electrochemical analyses were revealed using the human serum sample limit of detection (LOD) values of 40 and 33 nM, respectively. For point-of-care analysis, we developed a smartphone-integrated sensor array to calculate intensity changes, and the relative red/green/blue (RGB) values were measured at different concentrations of NE. The synthesized fluorescent probe is a promising candidate for detecting NE in biofluids. It is highly selective toward NE and is suitable for the early diagnosis of neurological diseases. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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