Genomic epidemiological analysis of a single-centre polyclonal outbreak of Serratia marcescens , Belgium, 2022 to 2023.

Autor:	Van Goethem S; Laboratory of Medical Microbiology, Vaccine and Infectious Diseases Institute, University of Antwerp, Antwerp, Belgium.; ZAS Hospital Network, Antwerp, Belgium., Xavier BB; Laboratory of Medical Microbiology, Vaccine and Infectious Diseases Institute, University of Antwerp, Antwerp, Belgium.; ZAS Hospital Network, Antwerp, Belgium., Glupczynski Y; Laboratory of Medical Microbiology, Vaccine and Infectious Diseases Institute, University of Antwerp, Antwerp, Belgium., Berkell M; Laboratory of Medical Microbiology, Vaccine and Infectious Diseases Institute, University of Antwerp, Antwerp, Belgium., Willems P; Multidisciplinary Unit of Infectious Diseases, GZA (ZAS) Hospitals, Antwerp, Belgium.; Laboratory of Medical Microbiology, GZA (ZAS) Hospitals, Antwerp, Belgium., Van Herendael B; Multidisciplinary Unit of Infectious Diseases, GZA (ZAS) Hospitals, Antwerp, Belgium.; Laboratory of Medical Microbiology, GZA (ZAS) Hospitals, Antwerp, Belgium., Hoet K; Multidisciplinary Unit of Infectious Diseases, GZA (ZAS) Hospitals, Antwerp, Belgium.; Laboratory of Medical Microbiology, GZA (ZAS) Hospitals, Antwerp, Belgium., Plaskie K; Multidisciplinary Unit of Infectious Diseases, GZA (ZAS) Hospitals, Antwerp, Belgium.; Department of Neonatology, GZA (ZAS) Hospitals, Antwerp, Belgium., Van Brusselen D; Multidisciplinary Unit of Infectious Diseases, GZA (ZAS) Hospitals, Antwerp, Belgium.; Department of Paediatrics, GZA (ZAS) Hospitals, Antwerp, Belgium.; Antwerp Paediatric Clinical Trial Network on vaccines and infectiology, University of Antwerp, Antwerp, Belgium., Goossens H; Laboratory of Medical Microbiology, Vaccine and Infectious Diseases Institute, University of Antwerp, Antwerp, Belgium., Malhotra-Kumar S; Laboratory of Medical Microbiology, Vaccine and Infectious Diseases Institute, University of Antwerp, Antwerp, Belgium.
Jazyk:	angličtina
Zdroj:	Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin [Euro Surveill] 2024 Nov; Vol. 29 (48).
DOI:	10.2807/1560-7917.ES.2024.29.48.2400144
Abstrakt:	Serratia marcescens is an opportunistic pathogen with a propensity to cause nosocomial outbreaks, particularly in neonatal intensive care units (NICUs). We present a sustained outbreak spanning over 18 months (1 January 2022-29 August 2023) in a NICU in Antwerp, Belgium, affecting 61 neonates, identified through samples taken for diagnostic purposes and by rectal screening. Ten neonates were infected: five with lower respiratory tract infection, four with conjunctivitis and one fatal case with sepsis. In a logistic regression analysis, nursing in an incubator was significantly associated with acquisition of S. marcescens (odds ratio (OR): 2.99; 95% confidence interval (CI): 1.14-8.25; p < 0.05). Whole genome sequencing-based multilocus sequence typing (wgMLST) and core genome single nucleotide polymorphism (cgSNP) analysis of isolates from clinical (n = 4), screening (n = 52) and environmental samples (n = 8), identified eight clusters and five singletons not associated with the clusters. Although outbreak measures were successful in containing further spread within the ward during sudden surges when > 4 cases per week were identified (peak events), several peaks with different clonal clusters occurred. The emergence of similar outbreaks in Belgian hospitals underscores the need of continuous surveillance and NICU-specific infection prevention and control (IPC) measures.
Databáze:	MEDLINE
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