The impact of diabetes on tight junctions in cardiomyopathy dysfunction.

Autor: Chodari L; Neurophysiology Research Center, Cellular and Molecular Medicine Research Institute, Urmia University of Medical Sciences, Urmia, Iran.; Department of Physiology, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran., Fatehfar S; Student Research Committee, Urmia University of Medical Sciences, Urmia, Iran., Ahmadi M; Medical Campus of Xi'an Jiaotong University, Xi'an, Shaanxi China., Ghorbanzadeh V; Cardiovascular Research Center, Shahid Rahimi Hospital, Lorestan University of Medical Sciences, Khorramabad, Iran.
Jazyk: angličtina
Zdroj: Journal of diabetes and metabolic disorders [J Diabetes Metab Disord] 2024 Jul 30; Vol. 23 (2), pp. 1645-1651. Date of Electronic Publication: 2024 Jul 30 (Print Publication: 2024).
DOI: 10.1007/s40200-024-01469-5
Abstrakt: Diabetic cardiomyopathy is a condition characterized by ventricular dysfunction in diabetic patients that is not caused by other cardiac ailments. It is associated with factors such as left ventricular hypertrophy, metabolic disturbances, and oxidative stress. Tight junctions, which form a barrier between cells, play a role in the vascular complications of diabetes. Proteins such as claudins and occludens are important for the structure and function of tight junctions. Zona occludens (ZO) proteins are also involved in tight junctions and their expression may be affected by diabetes. The review discusses the impact of diabetes on the tight junctions and the role of ZO proteins in diabetic cardiovascular dysfunction.
Competing Interests: Conflict of interestThe authors declare there is no conflict of interest.
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Databáze: MEDLINE
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