A decade of public engagement regarding human germline gene editing: a systematic scoping review.

Autor: Geuverink WP; Amsterdam UMC, location Vrije Universiteit Amsterdam, Department of Human Genetics, Amsterdam, the Netherlands.; Amsterdam Reproduction and Development Research Institute, Amsterdam, the Netherlands., Houtman D; Erasmus Medical Center, Department of Clinical Genetics, Rotterdam, the Netherlands., Retel Helmrich IRA; Erasmus Medical Center, Department of Clinical Genetics, Rotterdam, the Netherlands., Kist JD; Erasmus Medical Center, Department of Clinical Genetics, Rotterdam, the Netherlands., Henneman L; Amsterdam UMC, location Vrije Universiteit Amsterdam, Department of Human Genetics, Amsterdam, the Netherlands.; Amsterdam Reproduction and Development Research Institute, Amsterdam, the Netherlands., Cornel MC; Amsterdam UMC, location Vrije Universiteit Amsterdam, Department of Human Genetics, Amsterdam, the Netherlands.; Amsterdam Public Health Research Institute, Amsterdam, the Netherlands., Riedijk SR; Erasmus Medical Center, Department of Clinical Genetics, Rotterdam, the Netherlands. s.riedijk@erasmusmc.nl.
Jazyk: angličtina
Zdroj: European journal of human genetics : EJHG [Eur J Hum Genet] 2024 Nov 28. Date of Electronic Publication: 2024 Nov 28.
DOI: 10.1038/s41431-024-01740-6
Abstrakt: Following the discovery of the CRISPR-Cas technology in 2012, there has been a growing global call for public engagement regarding the potential use of human germline gene editing (HGGE). In this systematic scoping review, we aim to evaluate public engagement studies considering the following questions based on three points of attention: 1) Inclusion of underrepresented groups: who have been engaged? 2) Gathering values: what output has been reported? 3) Reaching societal impact: what objectives of public engagement have been reported? A systematic literature search from 2012 to 2023 identified 3464 articles reporting on public engagement studies regarding HGGE retrieved from 12 databases. After screening, 52 full-text articles were assessed for eligibility, resulting in 36 articles that cover 31 public engagement studies. We conclude that co-created efforts are needed to engage underrepresented groups as well as to yield values rather than acceptance levels, and to concretise how engagement might result in societal impact.
Competing Interests: Competing interests: As of 1st September 2022, the authors are involved in a Dutch Consortium “Public Realm Entrance of Human Germline Gene Editing” funded by the Dutch Research Council (NWO NWA.1389.20.075).
(© 2024. The Author(s).)
Databáze: MEDLINE
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