Polycyclic Aromatic Hydrocarbons Mediate the Association between Tobacco Smoking and Alcohol Use Disorder.

Autor:	Lee D; Department of Preventive Medicine, Yonsei University College of Medicine, Seoul, Korea., Bae MJ; Department of Occupational and Environmental Health, Yonsei University Graduate School, Seoul, Korea., Kim MJ; Department of Preventive Medicine and Institute of Health Science, Gyeongsang National University College of Medicine, Jinju, Korea., Oh SS; Department of Occupational and Environmental Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea., Park KS; Department of Preventive Medicine and Institute of Health Science, Gyeongsang National University College of Medicine, Jinju, Korea., Lee CJ; Division of Cardiology, Yonsei Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Korea., Park S; Division of Cardiology, Yonsei Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Korea., Lee SK; Department of Radiology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea., Koh SB; Department of Preventive Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea., Jung SJ; Department of Preventive Medicine, Yonsei University College of Medicine, Seoul, Korea.; Department of Public Health, Yonsei University Graduate School, Seoul, Korea.; Center for Global Health, Massachusetts General Hospital, Boston, MA, USA.; Harvard Center for Population and Development Studies, Cambridge, MA, USA., Kim C; Department of Preventive Medicine, Yonsei University College of Medicine, Seoul, Korea.; Department of Public Health, Yonsei University Graduate School, Seoul, Korea.; Institute of Human Complexity and Systems Science, Yonsei University, Incheon, Korea.; Institute for Environmental Research, Yonsei University College of Medicine, Seoul, Korea., Cho J; Department of Preventive Medicine, Yonsei University College of Medicine, Seoul, Korea.; Department of Public Health, Yonsei University Graduate School, Seoul, Korea.; Institute of Human Complexity and Systems Science, Yonsei University, Incheon, Korea.; Institute for Environmental Research, Yonsei University College of Medicine, Seoul, Korea. chojael@yuhs.ac.
Jazyk:	angličtina
Zdroj:	Yonsei medical journal [Yonsei Med J] 2024 Dec; Vol. 65 (12), pp. 752-760.
DOI:	10.3349/ymj.2023.0488
Abstrakt:	Purpose: Smoking is causally related to alcohol use disorder. Although polycyclic aromatic hydrocarbons (PAHs) are major neurotoxic pollutants in tobacco smoke, evidence is lacking on the role of PAHs in the relationship between smoking and alcohol use disorder. This study investigated the types of PAHs associated with smoking and whether exposure to those PAHs mediated the effect of smoking on alcohol use disorder. Materials and Methods: A total of 968 male firefighters were analyzed. Smoking history and cumulative pack-years were obtained using self-reported questionnaires. Alcohol use disorder was defined using the Alcohol Use Disorder Identification Test. PAH exposure was assessed by urinary metabolites. Regression analyses were performed between exposure (smoking), outcome (alcohol use disorder), and mediator (PAH metabolites) variables. A mediation analysis was performed to test the indirect effect of PAH metabolites on the association between smoking and alcohol use disorder. All analyses were repeated for 770 participants who were followed up after 2 years, while alcohol use disorder was redefined from follow-up data ensuring the temporal sequence of the variables. Results: Both 2-naphthol [β=0.78, 95% confidence interval (CI): 0.59-0.98] and 2-hydroxyfluorene (β=0.69, 95% CI: 0.56-0.82) were associated with smoking history. Furthermore, 2-naphthol and 2-hydroxyfluorene mediated the associations of smoking history (proportion mediated: 14.2%, 23.6% respectively) or cumulative pack-years (proportion mediated: 14.4%, 25.4% respectively) with alcohol use disorder. The results were consistent in longitudinal settings. Conclusion: Exposure to PAHs mediated the association between tobacco smoking and alcohol use disorder. PAH exposure from tobacco may increase the risk of addictive disorders. Competing Interests: The authors have no potential conflicts of interest to disclose. (© Copyright: Yonsei University College of Medicine 2024.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu