A mindfulness-based, cognitive, social, digital relapse-prevention intervention for youth with depression in Australia: study protocol for a randomised controlled trial of Rebound.

Autor:	Mangelsdorf SN; Orygen, Parkville, Victoria, Australia.; Centre for Youth Mental Health, The University of Melbourne, Parkville, Victoria, Australia., Cagliarini D; Orygen, Parkville, Victoria, Australia daniela.cagliarini@orygen.org.au.; Centre for Youth Mental Health, The University of Melbourne, Parkville, Victoria, Australia., Lee YY; Monash University Health Economics Group, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.; Queensland Centre for Mental Health Research, Wacol, Queensland, Australia.; School of Public Health, The University of Queensland, Herston, Queensland, Australia., Mihalopoulos C; Monash University Health Economics Group, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia., Liu V; Orygen, Parkville, Victoria, Australia., Valentine L; Orygen, Parkville, Victoria, Australia.; Centre for Youth Mental Health, The University of Melbourne, Parkville, Victoria, Australia., Bendall S; Orygen, Parkville, Victoria, Australia.; Centre for Youth Mental Health, The University of Melbourne, Parkville, Victoria, Australia., Koval P; Melbourne School of Psychological Sciences, The University of Melbourne, Parkville, Victoria, Australia.; Research Group of Quantitative Psychology and Individual Differences, KU Leuven, Leuven, Belgium., D'Alfonso S; School of Computing and Information Systems, The University of Melbourne, Parkville, Victoria, Australia., Davey C; Department of Psychiatry, The University of Melbourne, Parkville, Victoria, Australia., Russon P; School of Languages, Literatures, Cultures and Linguistics, Monash University, Melbourne, Victoria, Australia., Phillips J; School of Psychological Sciences, Monash University, Melbourne, Victoria, Australia., Gonzalez-Blanch C; Centre for Youth Mental Health, The University of Melbourne, Parkville, Victoria, Australia.; University Hospital Marques de Valdecilla-IDIVAL, Santander, Spain., Pawsey B; Mercy Health, Melbourne, Victoria, Australia., Ryan RM; Institute for Positive Psychology and Education, Australian Catholic University, North Sydney, New South Wales, Australia.; College of Education, Ewha Womans University, Seoul, South Korea., Parker A; Orygen, Parkville, Victoria, Australia.; Institute for Health and Sport, Victoria University, Melbourne, Victoria, Australia., Hetrick S; Department of Psychological Medicine, The University of Auckland, Auckland, New Zealand., Rice S; Orygen, Parkville, Victoria, Australia.; Centre for Youth Mental Health, The University of Melbourne, Parkville, Victoria, Australia.; Movember Men's Health Institute, Melbourne, Victoria, Australia., Lederman R; School of Computing and Information Systems, The University of Melbourne, Parkville, Victoria, Australia., Herrman H; Orygen, Parkville, Victoria, Australia.; Centre for Youth Mental Health, The University of Melbourne, Parkville, Victoria, Australia., Murray G; Centre for Mental Health and Brain Sciences, Swinburne University of Technology, Hawthorn, Victoria, Australia., Gleeson J; Healthy Brain and Mind Research Centre, School of Behavioural and Health Sciences, Australian Catholic University, Fitzroy, Victoria, Australia., Alvarez-Jimenez M; Orygen, Parkville, Victoria, Australia.; Centre for Youth Mental Health, The University of Melbourne, Parkville, Victoria, Australia.
Jazyk:	angličtina
Zdroj:	BMJ open [BMJ Open] 2024 Nov 27; Vol. 14 (11), pp. e088695. Date of Electronic Publication: 2024 Nov 27.
DOI:	10.1136/bmjopen-2024-088695
Abstrakt:	Introduction: Major depressive disorder (MDD) causes significant disease burden and functional impairment during adolescence and young adulthood. While most young people recover from their first episode, around two-thirds will experience one or more relapses, which can become more severe and treatment-resistant with each episode. To address relapse in MDD, we developed a moderated online social therapy platform (titled Rebound ) that integrates: (i) peer-to-peer social networking; (ii) tailored third-wave therapeutic content targeting mindfulness, self-compassion and rumination; and (iii) three types of human support (clinicians, peer workers, career consultants), informed by self-determination theory. The aim of this trial is to determine whether, in addition to treatment as usual (TAU), Rebound , an 18-month complex digital intervention, is superior to 18 months of enhanced TAU in preventing relapse and managing depressive symptoms. Methods and Analysis: This study is a rater-masked randomised controlled trial. The treatment conditions include Rebound plus TAU or enhanced TAU alone. We aim to recruit 255 young people with at least one episode of MDD, aged 14-27 years. The study includes monthly assessment points over 18 months. The study includes a 48-month recruitment period and an 18-month treatment phase. The primary outcome is depressive relapse at 18 months, as measured by the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), Research Version (SCID-5-RV). Secondary outcomes include the severity of depressive symptoms, time to relapse, time to remission, remission status, severity of anxiety symptoms, study and employment outcomes and cost-effectiveness. We will also examine four therapeutic mechanisms (mindfulness, self-compassion skills, social support and reduced rumination) to understand the 'how and why' of the intervention effects. Ethics and Dissemination: Melbourne Health Human Research Ethics Committee (HREC/42967/MH-2018) provided ethics approval for this study. Findings will be made available through scientific journals and forums and to the public via social media and the Orygen website. Trial Registration Number: ANZCTR, ACTRN12619001412123. Competing Interests: Competing interests: None declared. (© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY. Published by BMJ.)
Databáze:	MEDLINE
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