Analgesic effect of Keishinieppiittokajutsubu on low barometric pressure-induced pain response in arthritic model rats.

Autor:	Kurauchi Y; Department of Chemico-Pharmacological Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, 862-0973, Japan. Electronic address: kurauchy@kumamoto-u.ac.jp., Inoue K; Department of Chemico-Pharmacological Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, 862-0973, Japan. Electronic address: 207p1003@st.kumamoto-u.ac.jp., Kawakami T; Department of Chemico-Pharmacological Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, 862-0973, Japan. Electronic address: 190p1020@st.kumamoto-u.ac.jp., Ueda M; Kobayashi Pharmaceutical Co., Ltd., Ibaraki, Osaka, Japan. Electronic address: ma.ueda@kobayashi.co.jp., Yamaguchi T; Kobayashi Pharmaceutical Co., Ltd., Ibaraki, Osaka, Japan. Electronic address: tom.yamaguchi@kobayashi.co.jp., Akaki J; Kobayashi Pharmaceutical Co., Ltd., Ibaraki, Osaka, Japan. Electronic address: j.akaki@kobayashi.co.jp., Komorisono M; Kobayashi Pharmaceutical Co., Ltd., Ibaraki, Osaka, Japan. Electronic address: m.komorisono@kobayashi.co.jp., Katsuki H; Department of Chemico-Pharmacological Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, 862-0973, Japan. Electronic address: hkatsuki@gpo.kumamoto-u.ac.jp.
Jazyk:	angličtina
Zdroj:	Journal of pharmacological sciences [J Pharmacol Sci] 2024 Dec; Vol. 156 (4), pp. 230-234. Date of Electronic Publication: 2024 Oct 09.
DOI:	10.1016/j.jphs.2024.10.002
Abstrakt:	Rheumatoid arthritis (RA) is a disease that causes inflammation of joints, resulting in pain and swelling. Reduced barometric pressure induces painful symptom of RA, but there is no appropriate animal model and pharmacological evaluation. Keishinieppiittokajutsubu (KNEIJB), a Kampo medicine used to treat RA; however, its mechanism of action is not clear. Here, we found that KNEIJB suppressed the low barometric pressure (LP)-induced pain response in CFA-induced arthritic model rats. Furthermore, we found that KNEIJB reduced plasma IL-6 levels. These results suggest that KNEIJB might be beneficial in the treatment of RA or some other arthralgia induced by LP. Competing Interests: Declaration of competing interest The authors declare no potential conflicts of interest regarding this research and/or publication. (Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)
Databáze:	MEDLINE
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