Taste preference and conditioned taste aversion of the metallothionein-1/2 null mice.

Autor: Yasuura N; Oral Physiology, Department of Oral Functional Science, Division of Oral Medical Science, Faculty of Dental Medicine and Graduate School of Dental Medicine, Hokkaido University, Kita 13, Nishi 7, Kita-ku, Sapporo, 060-8586, Japan; Orthodontics, Department of Oral Functional Science, Division of Oral Medical Science, Faculty of Dental Medicine and Graduate School of Dental Medicine, Hokkaido University, Kita 13, Nishi 7, Kita-ku, Sapporo, 060-8586, Japan., Inui T; Oral Physiology, Department of Oral Functional Science, Division of Oral Medical Science, Faculty of Dental Medicine and Graduate School of Dental Medicine, Hokkaido University, Kita 13, Nishi 7, Kita-ku, Sapporo, 060-8586, Japan., Yoshizawa T; Oral Physiology, Department of Oral Functional Science, Division of Oral Medical Science, Faculty of Dental Medicine and Graduate School of Dental Medicine, Hokkaido University, Kita 13, Nishi 7, Kita-ku, Sapporo, 060-8586, Japan., Sogawa N; Department of Molecular Engineering and Drug Developmental Sciences, Graduate School of Oral Medicine, Matsumoto Dental University, Shiojiri, 399-0781, Japan., Sato Y; Orthodontics, Department of Oral Functional Science, Division of Oral Medical Science, Faculty of Dental Medicine and Graduate School of Dental Medicine, Hokkaido University, Kita 13, Nishi 7, Kita-ku, Sapporo, 060-8586, Japan., Funahashi M; Oral Physiology, Department of Oral Functional Science, Division of Oral Medical Science, Faculty of Dental Medicine and Graduate School of Dental Medicine, Hokkaido University, Kita 13, Nishi 7, Kita-ku, Sapporo, 060-8586, Japan. Electronic address: mfuna@den.hokudai.ac.jp.
Jazyk: angličtina
Zdroj: Physiology & behavior [Physiol Behav] 2025 Feb 01; Vol. 289, pp. 114757. Date of Electronic Publication: 2024 Nov 27.
DOI: 10.1016/j.physbeh.2024.114757
Abstrakt: To investigate the effects of metallothionein (MT)-1/2 gene knockout on the taste preference and the conditioned taste aversion (CTA), we performed an experiment comparing the behavior of wild type (WT) mice and MT-1/2 null (KO) mice. The taste preference ratio of saccharin solutions (0.1 or 0.2 %) was significantly greater in KO mice than WT mice. The preference ratio of salt and bitter solutions was not different between KO mice and WT mice. After feeding with a low zinc diet, the average saccharin preference ratio was not significantly different between WT and KO mice at any concentration of saccharin. Concentrations of zinc in plasma in KO mice was slightly higher than WT mice, but both were within the physiological range. When conditioning for saccharin using intraperitoneal injection of LiCl, a marked CTA was produced in both WT and KO mice. These results suggest that MT may be involved in the regulation of sweet taste preferences and indicate that the brain function that mediates sweet taste-induced CTA acquisition is maintained in KO mice. In addition, it was suggested that MT was not actively involved in the regulation of plasma zinc concentration in either mice fed a normal diet or mice fed a low zinc diet for a week. The relation between the malfunction of MT-1/2 and signal transduction of intracellular zinc remained to be determined.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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