Albizia ferruginea (Guill. & Perr.) Benth. leaf abates deregulation of P53, IRS, HsD17β2, FTO, and CYP11a genes in polycystic ovarian syndrome rat.

Autor:	Ogunlakin AD; Good Health and Wellbeing Research Cluster, 70671 Bowen University , Iwo, Nigeria.; Phytomedicine, Molecular Toxicology, and Computational Biochemistry Research Laboratory (PMTCB-RL), Department of Biochemistry, Bowen University, Iwo, Nigeria., Meruwoma MO; Phytomedicine, Molecular Toxicology, and Computational Biochemistry Research Laboratory (PMTCB-RL), Department of Biochemistry, Bowen University, Iwo, Nigeria., Ihiasota PO; Phytomedicine, Molecular Toxicology, and Computational Biochemistry Research Laboratory (PMTCB-RL), Department of Biochemistry, Bowen University, Iwo, Nigeria., Ojo OA; Good Health and Wellbeing Research Cluster, 70671 Bowen University , Iwo, Nigeria.; Phytomedicine, Molecular Toxicology, and Computational Biochemistry Research Laboratory (PMTCB-RL), Department of Biochemistry, Bowen University, Iwo, Nigeria., Adegoke AA; Department of Pharmacognosy, Faculty of Pharmacy, University of Ibadan, Ibadan. Nigeria., Akinwumi IA; Department of Pharmacognosy, Faculty of Pharmacy, Lead City University, Ibadan. Nigeria., Ambali OA; School of Medicine and Allied Health Sciences, University of the Gambia, Banjul, Gambia., Awosola OE; Next Era Health, Lagos, Nigeria., Sonibare MA; Department of Pharmacognosy, Faculty of Pharmacy, University of Ibadan, Ibadan. Nigeria.
Jazyk:	angličtina
Zdroj:	Journal of complementary & integrative medicine [J Complement Integr Med] 2024 Nov 29. Date of Electronic Publication: 2024 Nov 29.
DOI:	10.1515/jcim-2024-0287
Abstrakt:	Objectives: This study investigated the potential ameliorative effects of Albizia ferruginea leaves on letrozole-induced PCOS in Wistar rats. Methods: PCOS was induced in 25 female Wistar rats by administering letrozole (1 mg/kg), followed by treatment with 100 and 250 mg/kg body weight A. ferruginea leaf methanolic extract, as well as 1 mg/kg body weight of Clomiphene citrate as standard. Results: An acute toxicity study revealed a toxic dosage of 2,000 mg/kg for the plant extract. The A. ferruginea extract exhibited potent hydroxyl radical scavenging ability. Treatment with A. ferruginea leaf extract improved the irregular estrus cycle and hormonal imbalance. Additionally, the extract administration led to decreased testosterone and increased estradiol levels when compared to the untreated PCOS rat. Furthermore, methanol extract normalizes the levels of insulin receptor substrate (IRS), type 2 17-HSD (HsD17β2), P53, 11a-hydroxylase/17,20-desmolase (CYP11a), and fat mass and obesity-associated (FTO), genes in the cervix of PCOS rats. Conclusions: Overall, A. ferruginea demonstrated beneficial properties on polycystic ovary circumstances in rats, presenting its potential as a promising treatment for PCOS. (© 2024 Walter de Gruyter GmbH, Berlin/Boston.)
Databáze:	MEDLINE
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