Suppression of neurons in circumventricular organs enables months-long survival without water in thirteen-lined ground squirrels.

Autor: Junkins MS; Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT, USA.; Department of Neuroscience, Yale University School of Medicine, New Haven, CT, USA.; Department of Neuroscience and Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, New Haven, CT, USA., Feng NY; Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT, USA.; Department of Neuroscience, Yale University School of Medicine, New Haven, CT, USA.; Department of Neuroscience and Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, New Haven, CT, USA., Merriman DK; Department of Biology, University of Wisconsin-Oshkosh, Oshkosh, WI, USA., Bagriantsev SN; Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT, USA., Gracheva EO; Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT, USA.; Department of Neuroscience, Yale University School of Medicine, New Haven, CT, USA.; Department of Neuroscience and Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, New Haven, CT, USA.; Kavli Institute for Neuroscience, Yale University School of Medicine, New Haven, CT, USA.
Jazyk: angličtina
Zdroj: Science (New York, N.Y.) [Science] 2024 Nov 29; Vol. 386 (6725), pp. 1048-1055. Date of Electronic Publication: 2024 Nov 28.
DOI: 10.1126/science.adp8358
Abstrakt: Water deprivation is a life-threatening condition that engages a protective physiological response to couple osmolyte retention with potentiation of thirst. This response, typical for most mammals, safeguards against short-term water deprivation but fails in the long term. Thirteen-lined ground squirrels ( Ictidomys tridecemlineatus ) use the short-term response during summer, whereas during winter, they lack thirst and survive without water for months. In this work, we show that long-term thirst suppression occurs despite hormonal and behavioral signs of a substantial fluid deficit and originates from hypoactivity of neurons in the circumventricular organs, which exhibit marked functional suppression during winter that blunts their sensitivity to thirst cues. Our work reveals a notable capacity of the evolutionarily conserved brain regions that control fluid homeostasis in mammals to enable long-term survival without water.
Databáze: MEDLINE
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