Exploring the need for a preload on the estimation of permeability, vessel radius, and relative cerebral blood volume in MR vascular fingerprinting-based dynamic susceptibility contrast perfusion imaging.

Autor: van Dorth D; C. J. Gorter MRI Center, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands., Venugopal K; Department of Radiology and Nuclear Medicine, Erasmus Medical Center, University Medical Center Rotterdam, Rotterdam, Netherlands., van der Werff KN; Department of Radiology and Nuclear Medicine, Erasmus Medical Center, University Medical Center Rotterdam, Rotterdam, Netherlands., Smits M; Department of Radiology and Nuclear Medicine, Erasmus Medical Center, University Medical Center Rotterdam, Rotterdam, Netherlands.; Medical Delta, Delft, Netherlands.; Brain Tumor Center, Erasmus Medical Center Cancer Institute, Rotterdam, Netherlands., Warnert EAH; Department of Radiology and Nuclear Medicine, Erasmus Medical Center, University Medical Center Rotterdam, Rotterdam, Netherlands.; Brain Tumor Center, Erasmus Medical Center Cancer Institute, Rotterdam, Netherlands., Hernandez-Tamames JA; Department of Radiology and Nuclear Medicine, Erasmus Medical Center, University Medical Center Rotterdam, Rotterdam, Netherlands., van Osch MJP; C. J. Gorter MRI Center, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands.; Medical Delta, Delft, Netherlands., Poot DHJ; Department of Radiology and Nuclear Medicine, Erasmus Medical Center, University Medical Center Rotterdam, Rotterdam, Netherlands.
Jazyk: angličtina
Zdroj: Magnetic resonance in medicine [Magn Reson Med] 2024 Nov 28. Date of Electronic Publication: 2024 Nov 28.
DOI: 10.1002/mrm.30383
Abstrakt: Purpose: Dynamic susceptibility contrast (DSC) MRI is commonly part of the clinical brain tumor imaging protocol. Usually, a preload of contrast agent is administered to minimize contrast-leakage T 1 effects. However, recent studies have indicated that with adaptation of scan parameters (in particular, low flip angle), a preload is not required. For advanced approaches, like MR vascular fingerprinting (MRVF), which is based on combining gradient-echo and spin-echo readouts, excitation flip angles cannot easily be reduced, but postprocessing might alleviate leakage effects. In this study, the aim was to verify whether DSC-MRVF can be performed without preload.
Methods: A previously established simulation model was used to create a dictionary of DSC-MRVF signals resulting from a double-bolus injection with varying input values for permeability, vessel radius, and relative cerebral blood volume (rCBV). A sensitivity analysis based on a Cramer Rao Lower Bound approach was performed, from which the logarithmic ratio of standard deviations for parameter estimation was derived. A ratio above zero corresponded with a better determination without preload. Two brain tumor patients were included for validation.
Results: The results show that the standard deviation for determining permeability was lower without preload, whereas for determining rCBV, the opposite result was found. For vessel radius, the standard deviation was similar with and without preload. The in vivo data reasonably agreed with the simulation results.
Conclusion: This work has shown the potential of DSC-MRVF with a single bolus injection for determining vessel radius and permeability, although for rCBV, a preload is still advisable.
(© 2024 The Author(s). Magnetic Resonance in Medicine published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine.)
Databáze: MEDLINE
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