Exploring the management of recurrent angioedema caused by different mechanisms.
| Autor: | Mormile I; Department of Translational Medical Sciences, University of Naples Federico II, Naples., Suffritti C; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, SC Medicina - Emostasi e Trombosi, Milan., Bova M; Department of Medicine and Medical Specialties, A. Cardarelli Hospital, Naples, Italy. |
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| Jazyk: | angličtina |
| Zdroj: | Current opinion in allergy and clinical immunology [Curr Opin Allergy Clin Immunol] 2024 Nov 21. Date of Electronic Publication: 2024 Nov 21. |
| DOI: | 10.1097/ACI.0000000000001047 |
| Abstrakt: | Purpose of Review: We aim to explore the most recent insights into the pathogenesis of recurrent angioedema caused by different mechanisms and then focus on the management and treatment approaches available. Recent Findings: The recently developed DANCE consensus classification identifies five types of angioedema: mast cell-mediated (AE-MC), bradykinin-mediated, because of intrinsic vascular endothelium dysfunction (AE-VE), drug-induced (AE-DI), and due to unknown mechanisms (AE-UNK). These subtypes require different management with treatment choices targeting the main pathogenetic pathways involved in each form. For AE-MC and AE-BK, the therapeutic landscape has been significantly widened in recent years. Conversely, there is a lack of consensus for the hereditary forms because of newly discovered mutations (factor 12, plasminogen, kininogen-1, myoferlin, angiopoietin-1, heparan sulfate 3-O-sulfotransferase 6) and AE-UNK. Summary: Recurrent angioedema can present with or without wheals. Angioedema without wheals may be driven by bradykinin and/or mast cell mediators. The different forms respond to specific drugs and require a different management. For its potentially life-threatening and disfiguring features, angioedema should be promptly recognized and effectively treated. For this reason, enhancing awareness about various angioedema subtypes and their management provide a useful tool for the clinical practice. (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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