Appeal and Sensory Characteristics of Oral Nicotine Products in Young Adults Who Vape E-Cigarettes.

Autor:	Peraza N; Institute for Addiction Science, University of Southern California.; Department of Psychology, University of Southern California., Han DH; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California.; Institute for Addiction Science, University of Southern California., Whaley RC; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California.; Institute for Addiction Science, University of Southern California., Vogel EA; Health Promotion Research Center, University of Oklahoma Health Sciences Center., Monterosso JR; Institute for Addiction Science, University of Southern California.; Department of Psychology, University of Southern California., Gonzalez Anaya MJ; Institute for Addiction Science, University of Southern California., Patel DJ; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California.; Institute for Addiction Science, University of Southern California., Jafarzadeh NS; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California.; Institute for Addiction Science, University of Southern California., Hong K; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California., Mason TB; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California.; Institute for Addiction Science, University of Southern California., Tackett AP; Center for Tobacco Research at The James Comprehensive Cancer Center, The Ohio State University., Leventhal AM; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California.; Institute for Addiction Science, University of Southern California.; Department of Psychology, University of Southern California.
Jazyk:	angličtina
Zdroj:	Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco [Nicotine Tob Res] 2024 Nov 28. Date of Electronic Publication: 2024 Nov 28.
DOI:	10.1093/ntr/ntae281
Abstrakt:	Introduction: This study applied a novel tobacco regulatory science paradigm to characterize inter-product variation in the appeal and sensory features of emerging commercial and therapeutic oral nicotine products (ONPs) among young adults that vape e-cigarettes. Methods: Twenty-three young adults without ONP experience who use e-cigarettes completed a single-blind, single-visit remote lab study. Participants rated appeal and sensory characteristics during 5-minute standardized self-administrations of 8 ONPs (4 fruit, 4 mint) from various brands (Lucy, Rouge, Solace, Nicorette, On!, Velo). Participants were randomized between-subjects to ONP type (pouches or gum). Results: Gum ONPs were rated sweeter (B = 19.5, 95% CI = 4.3, 34.7), stronger in flavor (B = 25.6, 95% CI = 12.2, 39.0), and lower in tingling sensation (B = -14.0, 95% CI = -27.8, -0.2) than pouches. Fruit-flavored ONPs were sweeter (B = 12.9, 95% CI = 6.1, 19.7) and caused less burning (B = -12.0, 95% CI = -19.5, -4.5) than mint. Product type x flavor interactions found that gum vs. pouch enhanced sweetness and flavor strength more for fruit than mint, while pouch vs. gum increased burning and harshness more for mint. Nicorette White Ice was most appealing, while Rogue Fruit and Nicorette Mint were less so. Appeal correlated with most types of sensory experiences (rs = -.33-.54), except for tingling and burning. Conclusions: Nicotine gums may offer a more pleasant sensory experience than pouches for young adults who use e-cigarettes, with variation across brand/flavor variants. Implications: Results indicate that gum ONPs and fruit flavors may offer greater appeal and a more pleasant sensory experience than pouch ONPs and mint flavors for young adults who use e-cigarettes and are ONP-naïve, with heterogeneity in user experience across some brand/flavor variants. This study also introduces a method for assessing the appeal and sensory features of ONPs, which can inform regulatory efforts and strategies to reduce nicotine dependence among young adults who use e-cigarettes. (© The Author(s) 2024. Published by Oxford University Press on behalf of the Society for Research on Nicotine and Tobacco. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.)
Databáze:	MEDLINE
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