Impact of stereotactic radiotherapy for craniopharyngioma: a large, academic hospital cohort.

Autor: Mauro GP; Department of Radiology and Oncology - Discipline of Radiotherapy, Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, SP, Brazil. geovanne95@gmail.com., Da Róz LM; Department of Neurology - Discipline of Neurosurgery, Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, SP, Brazil., Gico VC; Department of Radiation Oncology, Instituto do Câncer do Estado de São Paulo (ICESP), Medical School of Sao Paulo University, São Paulo, Brazil., Weltman E; Department of Radiology and Oncology - Discipline of Radiotherapy, Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, SP, Brazil.; Department of Radiation Oncology, Hospital Israelita Albert Einstein, São Paulo, SP, Brazil., de Souza EC; Department of Neurology - Discipline of Neurosurgery, Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, SP, Brazil., Villar RC; Department of Radiology and Oncology - Discipline of Radiotherapy, Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, SP, Brazil., Matushita H; Department of Neurology - Discipline of Neurosurgery, Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, SP, Brazil., Carlotti CG; Department of Neurology - Discipline of Neurosurgery, Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, SP, Brazil.
Jazyk: angličtina
Zdroj: Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery [Childs Nerv Syst] 2024 Nov 28; Vol. 41 (1), pp. 11. Date of Electronic Publication: 2024 Nov 28.
DOI: 10.1007/s00381-024-06686-0
Abstrakt: Purpose: Adjuvant radiotherapy has been a standard of care for craniopharyngioma. Nevertheless, it is a rare disease with multiple presentations, and results with conservative surgery followed by radiotherapy (RT) can vary. We compared treatment results for both adult and pediatric patients.
Methods: This is a retrospective cohort of patients treated between 2010 and 2023 in a single university hospital.
Results: Seventy-nine patients' clinical data was assessed. Median follow-up was 75.5 months (7.1-210.2 months). Median age was 24.4 years, and 40 (50.6%) were considered pediatric patients. Median lesion size after surgery was 3.4 cm (range 0.4 to 10.4 cm). Ten patients (16.9%) were submitted to Ommaya reservoir placement surgery, and most (70%) have lesion reductions that impact radiotherapy planning. Timing of radiotherapy whether adjuvant or salvage did not impact progression-free survival (PFS) (p = 0.39). Median PFS was not reached, and mean PFS was 65.7 months. Disease control was obtained in 67 (84.1%) patients.
Conclusion: We achieved great results with consisting institutional protocol in both adult and childhood craniopharyngioma. Timing of RT did not translate into loss of disease control in our study, with good results for salvage radiotherapy. Ommaya reservoirs can impact RT planning, but not outcomes.
Competing Interests: Declarations. Competing interests: The authors declare no competing interests.
(© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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