Gold-catalyzed hydrofluorination of terminal alkynes using potassium bifluoride (KHF 2 ).

Autor:	Pronovost R; PROTEO, CCVC, Département de chimie, Université Laval, 1045 avenue de la Médecine, Québec, QC, G1V 0A6, Canada. jean-francois.paquin@chm.ulaval.ca., Rion M; PROTEO, CCVC, Département de chimie, Université Laval, 1045 avenue de la Médecine, Québec, QC, G1V 0A6, Canada. jean-francois.paquin@chm.ulaval.ca., Tzouras NV; Department of Chemistry and Centre for Sustainable Chemistry, Ghent University, Krijgslaan 281, S-3, 9000 Ghent, Belgium., Nolan SP; Department of Chemistry and Centre for Sustainable Chemistry, Ghent University, Krijgslaan 281, S-3, 9000 Ghent, Belgium., Paquin JF; PROTEO, CCVC, Département de chimie, Université Laval, 1045 avenue de la Médecine, Québec, QC, G1V 0A6, Canada. jean-francois.paquin@chm.ulaval.ca.
Jazyk:	angličtina
Zdroj:	Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2024 Dec 12; Vol. 60 (100), pp. 15035-15038. Date of Electronic Publication: 2024 Dec 12.
DOI:	10.1039/d4cc05049e
Abstrakt:	A gold-catalyzed hydrofluorination of terminal alkynes is reported. The salient features of this study showcase the use of potassium bifluoride, KHF 2 , as the fluorinating agent in conjunction with a fluorinated solvent, hexafluoroisopropanol. The reaction is mediated by a well-defined precursor, [Au(IPr)(OH)] with an acid activator. A wide range of functionalized terminal alkynes can be converted to the corresponding monofluoroalkenes in up to 97% yield.
Databáze:	MEDLINE
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