Pancreatic Leiomyosarcoma With Multi-organ Metastases: A Rare Case.

Autor:	Alnaqbi S; Oncology, Tawam Hospital, Al Ain, ARE., Kumar P; Oncology, Tawam Hospital, Al Ain, ARE., Bin Sumaida A; Oncology/Radiation Oncology, Tawam Hospital, Al Ain, ARE., Shanbhag NM; Internal Medicine, College of Health Sciences, United Arab Emirates University, Al Ain, ARE.; Radiation Oncology/Palliative Care, Tawam Hospital, Al Ain, ARE., Ahmad AZ; Pathology, PureLab, Abu Dhabi, ARE., Balaraj K; Oncology/Radiation Oncology, Tawam Hospital, Al Ain, ARE.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2024 Oct 28; Vol. 16 (10), pp. e72520. Date of Electronic Publication: 2024 Oct 28 (Print Publication: 2024).
DOI:	10.7759/cureus.72520
Abstrakt:	This case report describes the diagnosis, treatment, and progression of a 50-year-old male patient diagnosed with stage IV pancreatic leiomyosarcoma with metastases to the liver, lungs, and brain, representing the only case involving both the pancreas and brain documented in the hospital registry with a histopathological diagnosis of leiomyosarcoma. The patient initially presented with chronic abdominal pain, constipation, and weight loss, and subsequent CT scans revealed a large pancreatic mass with metastases to the liver, lungs, and brain. A biopsy confirmed the diagnosis of leiomyosarcoma, and the patient underwent eight cycles of palliative chemotherapy with cisplatin and docetaxel, along with palliative radiotherapy targeting the brain metastases. Despite these interventions, the disease progressed, resulting in the patient experiencing altered mental status, generalized weakness, and seizure-like activity, reflecting the impact of the brain metastases and overall disease progression. His management included treatment with dexamethasone, antiseizure medications, and supportive care, while discussions about palliative care options were conducted with the family. This rare case highlights the aggressive nature of pancreatic leiomyosarcoma, characterized by rapid progression and resistance to chemotherapy and radiotherapy, with the involvement of multiple organ systems demonstrating the challenges associated with managing advanced metastatic leiomyosarcoma. Competing Interests: Human subjects: Consent for treatment and open access publication was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. (Copyright © 2024, Alnaqbi et al.)
Databáze:	MEDLINE
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