Divergent Visuomotor Strategies in Teleosts: Neural Circuit Mechanisms in Zebrafish and Danionella cerebrum .
| Autor: | Fouke KE, He Z, Loring MD, Naumann EA |
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| Jazyk: | angličtina |
| Zdroj: | BioRxiv : the preprint server for biology [bioRxiv] 2024 Nov 23. Date of Electronic Publication: 2024 Nov 23. |
| DOI: | 10.1101/2024.11.22.624938 |
| Abstrakt: | Many animals respond to sensory cues with species-specific coordinated movements to successfully navigate their environment. However, the neural mechanisms that support diverse sensorimotor transformations across species with distinct navigational strategies remain largely unexplored. By comparing related teleost species, zebrafish ( Danio rerio, ZF ) and Danionella cerebrum ( DC ), we investigated behavioral patterns and neural architectures during the visually guided optomotor response (OMR). Closed-loop behavioral tracking during visual stimulation revealed that larval ZF employ burst-and-glide locomotion, while larval DC display continuous, smooth swimming punctuated with sharp directional turns. Although DC achieve higher average speeds, they lack the direction-dependent velocity modulation observed in ZF . Whole-brain two-photon calcium imaging and tail tracking in head-fixed fish reveals that both species exhibit direction-selective motion encoding in homologous regions, including the retinorecipient pretectum, with DC exhibiting fewer binocular, direction-selective neurons overall. Kinematic analysis of head-fixed behavior reveals that DC sustain significantly longer directed swim events across all stimuli than ZF , highlighting the divergent visuomotor strategies, with ZF reducing tail movement duration in response to oblique, turn-inducing stimuli. Lateralized motor-associated neural activity in the medial and anterior hindbrain of both species suggests a shared circuit motif, with distinct neural circuits that independently control movement vigor and direction. These findings highlight the diversity in visuomotor strategies among teleost species, underscored by shared sensorimotor neural circuit motifs, and establish a robust framework for unraveling the neural mechanisms driving continuous and discrete visually guided locomotion, paving the way for deeper insights into vertebrate sensorimotor functions. Research Highlights: Larval DC exhibit faster swimming than ZF , matching the direction of visual motion. DC execute OMR in smooth, curved swimming patterns, interspersed with sharp directional turns. ZF and DC share similar visuomotor neural architecture, recruiting pretectal and hindbrain regions. ZF and DC demonstrate lateralized encoding of turns, particularly in medial hindbrain neurons. In Brief: Larval Danionella cerebrum respond to global visual motion cues in smooth, low-angle swimming patterns, interspersed with sharp directional turns, swimming consistently faster than zebrafish. Fouke et al. use behavioral tracking of freely moving and head fixed fish to reveal an evolutionarily conserved visuomotor neural architecture transforming visual motion cues into species-specific locomotor behaviors. |
| Databáze: | MEDLINE |
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