Thioether-Functionalized Cellulose for the Fabrication of Oxidation-Responsive Biomaterial Coatings and Films.

Autor: DuBois EM; Department of Biomedical Engineering, Boston University, Boston, MA, 02215-2407, USA., Herrema KE; Department of Biomedical Engineering, Boston University, Boston, MA, 02215-2407, USA., Simkulet MG; Department of Biomedical Engineering, Boston University, Boston, MA, 02215-2407, USA., Hassan LF; Department of Biomedical Engineering, Boston University, Boston, MA, 02215-2407, USA., O'Connor PR; Department of Biomedical Engineering, Boston University, Boston, MA, 02215-2407, USA.; Department of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, NY, 12180-3590, USA., Sen R; Department of Biomedical Engineering, Boston University, Boston, MA, 02215-2407, USA.; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, 30332, USA., O'Shea TM; Department of Biomedical Engineering, Boston University, Boston, MA, 02215-2407, USA.
Jazyk: angličtina
Zdroj: Advanced healthcare materials [Adv Healthc Mater] 2024 Nov 27, pp. e2403021. Date of Electronic Publication: 2024 Nov 27.
DOI: 10.1002/adhm.202403021
Abstrakt: Biomaterial coatings and films can prevent premature failure and enhance the performance of chronically implanted medical devices. However, current hydrophilic polymer coatings and films have significant drawbacks, including swelling and delamination. To address these issues, hydroxyethyl cellulose is modified with thioether groups to generate an oxidation-responsive polymer, HEC MTP . HEC MTP readily dissolves in green solvents and can be fabricated as coatings or films with tunable thicknesses. HEC MTP coatings effectively scavenge hydrogen peroxide, resulting in the conversion of thioether groups to sulfoxide groups on the polymer chain. Oxidation-driven, hydrophobic-to-hydrophilic transitions that are isolated to the surface of HEC MTP coatings under physiologically relevant conditions increase wettability, decrease stiffness, and reduce protein adsorption to generate a non-fouling interface with minimal coating delamination or swelling. HEC MTP can be used in diverse optical applications and permits oxidation-responsive, controlled drug release. HEC MTP films are non-resorbable in vivo and evoke minimal foreign body responses. These results highlight the versatility of HEC MTP and support its incorporation into chronically implanted medical devices.
(© 2024 Wiley‐VCH GmbH.)
Databáze: MEDLINE
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