Evolutionary plasticity in nematode Hox gene complements and genomic loci arrangement.

Autor: Kirangwa J; Institut für Zoologie, Universität zu Köln, Zülpicher str. 47b, 50674, Cologne, Germany. jkirangw@uni-koeln.de., Laetsch DR; Institute of Evolutionary Biology, University of Edinburgh, EH9 3FL, Edinburgh, Scotland., King E; Wellcome Sanger Institute, Tree of Life, Wellcome Genome Campus, Cambridge, CB10 1SA, UK., Stevens L; Wellcome Sanger Institute, Tree of Life, Wellcome Genome Campus, Cambridge, CB10 1SA, UK., Blaxter M; Wellcome Sanger Institute, Tree of Life, Wellcome Genome Campus, Cambridge, CB10 1SA, UK., Holovachov O; Department of Zoology, Swedish Museum of Natural History, 104 05, Stockholm, Sweden., Schiffer P; Institut für Zoologie, Universität zu Köln, Zülpicher str. 47b, 50674, Cologne, Germany. p.schiffer@uni-koeln.de.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Nov 27; Vol. 14 (1), pp. 29513. Date of Electronic Publication: 2024 Nov 27.
DOI: 10.1038/s41598-024-79962-3
Abstrakt: Hox genes are central to metazoan body plan formation, patterning and evolution, playing a critical role in cell fate decisions early in embryonic development in invertebrates and vertebrates. While the archetypical Hox gene cluster consists of members of nine ortholog groups (HOX1-HOX9), arrayed in close linkage in the order in which they have their anterior-posterior patterning effects, nematode Hox gene sets do not fit this model. The Caenorhabditis elegans Hox gene set is not clustered and contains only six Hox genes from four of the ancestral groups. The pattern observed in C. elegans is not typical of the phylum, and variation in orthologue set presence and absence and in genomic organisation has been reported. Recent advances in genome sequencing have resulted in the availability of many novel genome assemblies in Nematoda, especially from taxonomic groups that had not been analysed previously. Here, we explored Hox gene complements in high-quality genomes of 80 species from all major clades of Nematoda to understand the evolution of this key set of body pattern genes and especially to probe the origins of the "dispersed" cluster observed in C. elegans. We also included the recently available high-quality genomes of some Nematomorpha as an outgroup. We find that nematodes can have Hox genes from up to six orthology groups. While nematode Hox "clusters" are often interrupted by unrelated genes we identify species in which the cluster is intact and not dispersed.
Competing Interests: Declarations. Competing interests: The authors declare no competing interests.
(© 2024. The Author(s).)
Databáze: MEDLINE
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