Breaking down IgA: Tomasiella immunophila enlightens microbiome-immune interactions.

Autor: Sutherland DB; Ludwig Group, Environmental Engineering Institute, School of Architecture, Civil and Environmental Engineering, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland., Kato LM; Laboratory for Mucosal Immunity, Center for Integrative Medical Sciences, RIKEN Yokohama Institute, Yokohama, Japan. Electronic address: lucia.kato@riken.jp., Fagarasan S; Laboratory for Mucosal Immunity, Center for Integrative Medical Sciences, RIKEN Yokohama Institute, Yokohama, Japan; Division of Integrated High-Order Regulatory Systems, Center for Cancer Immunotherapy and Immunobiology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Jazyk: angličtina
Zdroj: Trends in immunology [Trends Immunol] 2024 Nov 26. Date of Electronic Publication: 2024 Nov 26.
DOI: 10.1016/j.it.2024.11.003
Abstrakt: The recent discovery by Lu and colleagues of Tomasiella immunophila, a bacterium that degrades IgA, offers insights into microbial influences on mucosal immunity and evolutionary immune trade-offs. By modulating IgA titers, T. immunophila influences the dynamic interactions and balance between the host and pathogen. This has implications for immune health, microbiome research, and therapeutics.
Competing Interests: Declaration of interests None declared by authors.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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